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1.A.17.4.9
Tmc receptor/channel of 1932 aas and about 10 TMSs. Plays a role in Drosophila proprioception and the sensory control of larval locomotion (Guo et al. 2016). These Tmc channels may be activated by membrane curvature in dendrites that are exposed to strain, possibly explaining how different cellular systems rely on a common molecular pathway for mechanosensory responses (He et al. 2019).

Accession Number:M9NDN5
Protein Name:CG3280
Length:1932
Molecular Weight:216669.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:10
Substrate Unknown

Cross database links:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQSSADAKRE FYKGQRGRRA ASQEDHRSYE LNDFPLQNQS SDAESCHQEP HFAHQRSPGI 
61:	GFDEDGGGGD IDDEESYTIS VSAIMQRRAS VRGYRGKRGS RSSRRASSPM DHVLDSVERR 
121:	RSSVYTTSSE EGTNQESTQE QIFENIRLHK EVIQSVKLQP WPIRKKLKLV RQAKTYVARH 
181:	EGALQERFAM SRSTRDLWAR FKILMAARWR HWKRETASFL TVLIPWELRI KEIESHFGSG 
241:	VASYFTFLRW LMWVNIMIAI PLVAFVIGPE YFATKHGETD PRKRMSDPEA RVAGNLFTFW 
301:	EFEGYLKYSP MFYGYYSSTS GISTSGYKLP LAYFLTAVLV YIYSFVATLR KMAENSRNSK 
361:	LSSKDDECVF SWKLFTGWDF MIGHAETAHN RIASVVVGFK EALLEEAEKK KDNRNWRVIL 
421:	QRILVNILVM GLLGLSGATV VLLVNHSEDL AKHDNWLSRN AVNVTMTLLS FFLPMIFEAL 
481:	GLFENWHPRQ QLRLQLARIM ILNMLNLYSL MFSFIYKINS KEKPLQMLKL ENETNTMELK 
541:	NLLSSIEALR AMTPTTSLYG ESTSDGLFDD STSTATWGED GGGLFSTTAA AALISTTVQR 
601:	LKCYNMTVKC SKLRRNIISG KHLATTLMVL NLTTPAMVPP TLPTTLPTTF PTTLPTTLPT 
661:	TLPTALPTTL PTTLPTTLPS TLATTTATTS SIWSTTEETS PTTTTTSPWT TLPPSTTTTE 
721:	ATTTTERATT TTEATSTTTL KITTAEINST LSDTTKPLGK SIDTEIPNST TNSATLSTIP 
781:	ATLNTTNLPL NSTTKLTTTT STEKPQGEDN FIYTTGEDEG SYDYGSDSTS DAPDNNSYSD 
841:	ITDYSSEPSE IEDFDEQEST DQADDPLAKV LEQLDENETK GRRKRALAES PFFTSKYSRR 
901:	HRNESAVSAG QPRETTESVN ATPSRWPFNW ASFRQTTPRT TTTRRVPSGI LTKEEWERLR 
961:	RLRGRITTTT STSTTSTTTR RPRWRYRTTT TELTSTTEEE SSTTESSTDS SSPGSTTNAF 
1021:	DSSSSTTEED EYTTTEGSEN RPYYVGYVDI SEMGSTIYYD GDSEFLEECV ITICPKGDDF 
1081:	FGSTTESPDS TTQSSDSKQL TTVKLTPLER KQKRLKEVQL AIKQIQTNLT TMCWETSLGQ 
1141:	ELSKVIVFDG LMSIVAPLCI DFLRALFVRY VNQNWCWDME KTFPQYGDFK IAENILTLIN 
1201:	NQGQVWMGIF FSPGLVLINL VKLMIMMYFR SWIVLTCNVP HEVVFKASKS NNFYLSLLLT 
1261:	MLFLCVLPVG YAIVWLRPSW HCGPFSEYNR IAEFITNTTR NALPKQLHEP LDYLTSSSTV 
1321:	IPLLLLLILI IYYLVSLTGA LREANQDLRT QLQKEREEER KKIFKVPEVK QAEPTATTLT 
1381:	NRWRKVLEAS SPVTPTQPPD FDTEEYKNQA RKELISRIMK KALRKGSATS DEDSFVRRDD 
1441:	DDTDTEHQDS LPHDEEAKDK RFGLSRLQQI RRTRKPSLVD IVQIAKQERA RAGSIVAGTS 
1501:	SSGTGNFPIK ETHPKSRFKV EKHERKDRGS MKDKKDTRHR QSPQQQQQPP PYESPKDNEH 
1561:	DPDTNSRIVS ASLLRRHKEQ AEGEEPPTTP DAPQTPNSPV EPVEQALEES TPETPTLAKS 
1621:	KFHIVDEKKP PPHEVEDKPL PTPKESGSGG GSLGKFKFRK HKFKSNNVAA VKPEPEVFKF 
1681:	DERSVERSSD VPATHAAEYL NNEPSGTEEQ DRSLPSPTPS QGQGHHQRQL SVLSRQGRKK 
1741:	IGNLLALVRE AVNLKKDDVE QAGSDESPGP TTPTYLAYTP PPPPSVLSSV SSSTALEMPP 
1801:	TPEPESPTPS APLHFGSSTS SRAPSKPPKP PMVPASATAP TATMDDLEEL DTAGPITFPR 
1861:	RSDSHRRRTM RQDSQSSIWS DNIPTITIST TGSDECIVDA AAPQNGLPDP RSASPEPTVN 
1921:	IIRIDIENEH EK