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1.A.17.5.20
Dimeric OSCA1.2 of 766 aas and 11 TMSs.  The 3-D structure has been determined (K. Maity et al., PNAS, in press).  This protein is 69% identical to the A. thaliana ortholog (TC# 1.A.17.5.10). It is a putative early stress-responsive osmolality-sensing ion channel protein. A model has been proposed by which it may mediate hyperosmolality-sensing and consequent gating of ion transport. It has a cytosolic domain structurally related to RNA recognition proteins that includes helical arms paralell to the plane of the membrane.  They may sense lateral tension in the inner leaflet, caused by changes in turgor pressure, allowing gating of the channel via coupling of the two domains.

Accession Number:Q5TKG1
Protein Name:Os05g0594700 protein
Length:766
Molecular Weight:87927.00
Species:Oryza sativa subsp. japonica (Rice) [39947]
Number of TMSs:10
Substrate

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FASTA formatted sequence
1:	MATVSDIGLS AAINVSMAVA FLLVFAFLRL QPINDRVYFP KWYLRGMRDS PVSSGAAVQK 
61:	VVNLNMRSYL KFLSWMPAAL KMPEDELINH AGLDSAVYLR IYLTGIKIFV PISILASLVL 
121:	FPVNWTNDTL DSMKVVHSKI DKLSISNIPY GSNRFVTHLV MAYAVTFWTC YVLFREYEII 
181:	TTMRLRFLAS EKRRPDQFTV LVRNIPPDPD ESISELVEHF FLVNHPDHYL RHQVVYNANK 
241:	LADLVEKKKK LQNWLDYYQL KYERNPSKRP TTKTGFLGCF GSEVDAIEYY KAEIEKIGKE 
301:	EADERQKIMK DPQSAVPAAF VSFRSRWGAA VCAQTQQTSN PTVWITEWAP EPRDVYWNNL 
361:	SIPFVSLTVR RLIVAVAFFF LNFFYVIPIA FVQSLASLEG IEKALPFLKP LIKIDVIKSF 
421:	IQGFLPGIAL KVFLILLPTI LMFMSKFEGL ISQSSLERRS ASKYYIFLFF NVFLGSIVTG 
481:	SALDQLKAYI HQSANEIPRT IGVAIPMRAT FFITYVMVDG WTGVAGEILR LRALIIFHLK 
541:	NFFLVKTEKD REEAMDPGSI CFDWCEPRIQ LYFLLGLVYA VVTPLLLPFI LVFFGLAYVV 
601:	YRHQIINVYN QQYESGAQFW PSVHGRIIIA LIVSQLLLIG LLSTKGFEET TPVLVVLPVL 
661:	TFWFYKYCKN RFEPAFVRNP LQEAMRKDTL ERAREPTFDL KAYLANAYLH PVFKGREEED 
721:	NMSISEDVGM EEVIVPTKRQ SRRNTPAQSK YEGSDTLSLP ETVHER