|Protein Name:||Apoptosis regulator BAX|
|Species:||Homo sapiens (Human) |
|Number of TMSs:||2|
|Location1 / Topology2 / Orientation3:||Cytoplasm1|
Cross database links:
|RefSeq:||NP_004315.1 NP_620116.1 NP_620118.1 NP_620119.2|
|Entrez Gene ID:||581|
GO:0005789 C:endoplasmic reticulum membrane
GO:0005741 C:mitochondrial outer membrane
GO:0005757 C:mitochondrial permeability transition pore ...
GO:0051434 F:BH3 domain binding
GO:0008289 F:lipid binding
GO:0046982 F:protein heterodimerization activity
GO:0042803 F:protein homodimerization activity
GO:0008635 P:activation of caspase activity by cytochrome c
GO:0001783 P:B cell apoptosis
GO:0006922 P:cleavage of lamin
GO:0006309 P:DNA fragmentation involved in apoptosis
GO:0010248 P:establishment or maintenance of transmembra...
GO:0008624 P:induction of apoptosis by extracellular sig...
GO:0008629 P:induction of apoptosis by intracellular sig...
GO:0046674 P:induction of retinal programmed cell death
GO:0043653 P:mitochondrial fragmentation during apoptosis
GO:0008053 P:mitochondrial fusion
GO:0008634 P:negative regulation of survival gene produc...
GO:0030264 P:nuclear fragmentation during apoptosis
GO:0043525 P:positive regulation of neuron apoptosis
GO:0051260 P:protein homooligomerization
GO:0051881 P:regulation of mitochondrial membrane potential
GO:0043497 P:regulation of protein heterodimerization ac...
GO:0043496 P:regulation of protein homodimerization acti...
GO:0001836 P:release of cytochrome c from mitochondria
GO:0032976 P:release of matrix enzymes from mitochondria
GO:0009636 P:response to toxin
GO:0006927 P:transformed cell apoptosis
 “Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.” Oltvai Z.N.et.al. 8358790
 “Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.” Apte S.S.et.al. 7607685
 “Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains.” Shi B.et.al. 9920818
 “Characterization of Bax-sigma, a cell death-inducing isoform of Bax.” Schmitt E.et.al. 10772918
 “The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.” Cartron P.F.et.al. 11912183
 “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039
 “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334
 “Bax mutations in cell lines derived from hematological malignancies.” Meijerink J.P.P.et.al. 7475270
 “A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.” Chittenden T.et.al. 8521816
 “Conformation of the Bax C-terminus regulates subcellular location and cell death.” Nechushtan A.et.al. 10228148
 “Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.” Cuddeback S.M.et.al. 11259440
 “Humanin peptide suppresses apoptosis by interfering with Bax activation.” Guo B.et.al. 12732850
 “JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.” Tsuruta F.et.al. 15071501
 “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330
 “Structure of Bax: coregulation of dimer formation and intracellular localization.” Suzuki M.et.al. 11106734
|Predict TMSs (Predict number of transmembrane segments)|
|FASTA formatted sequence||
1: MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS 61: ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL 121: VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV 181: LTASLTIWKK MG