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1.A.23.8.1
CmpX of 274 aas and 5 TMSs in a 1 + 4 arrangement. CmpX regulates virulence and controls biofilm formation in P. aeruginosa (Bhagirath et al. 2017). It also modulates intra-cellular c-di-GMP levels. A cmpX knockout showed decreased promoter activity of exoS (PA1362) and increased activity of the small RNA, RsmY. As compared to the wild-type PAO1, the cmpX mutant had elevated intracellular c-di-GMP levels as well as increased expression of wspR (PA3702), a c-di-GMP synthase. Transcription of the major outer membrane porin gene oprF (PA1777) and sigma factor sigX (PA1776) was decreased in the cmpX mutant. The cmpX knockout mutant had increased sensitivity to membrane detergents and antibiotics such as lauryl sulfobetaine, tobramycin, and vancomycin (Bhagirath et al. 2017).

Accession Number:G3XCV6
Protein Name:Conserved cytoplasmic membrane protein, CmpX protein
Length:274
Molecular Weight:29019.00
Species:Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) [208964]
Number of TMSs:5
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQFDIWTQSL LTAMNTLWGK LAGFIPNLLG ALVVVLLGFV IAKLLDALLS KLLAKLGLDR 
61:	LMGGTGLTKL LARVGIQVPV STLVGKIVYW FVLLVFLVSA AESLGLQRVS ATLDVLALYL 
121:	PKVFGAALVL IVGVLLAQLV NSVVRGAADG VGLEYANGLG RIAQWLVIII SISVAVGQLE 
181:	VKTDLLNYII AIVLITVGLA AALALGLGSR EVAGQIIAGI YVRELYQVGQ QVKVGDVEGT 
241:	IEEIGTVKTI LLTEEGELVS LANRLLLDQR VTSR