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1.A.25.3.7
Leucine-rich repeat-containing protein 59, LRRC59, of 307 aas and 1 C-terminal TMS. It is a tail-anchored protein  that localizes to the ER and the nuclear envelope and is required for nuclear import of FGF1. It might regulate nuclear import by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pore (TC# 1.I.1) (Zhen et al. 2012). LRRC59 is post-translationally inserted into ER-derived membranes, possibly by diffusion (Blenski and Kehlenbach 2019).


Accession Number:Q96AG4
Protein Name:Leucine-rich repeat-containing protein 59
Length:307
Molecular Weight:34930.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Microsome membrane1 / Single-pass type II membrane protein2
Substrate

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FASTA formatted sequence
1:	MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG 
61:	LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL 
121:	DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK 
181:	EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK 
241:	HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV 
301:	LQTDSQQ