TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.26.1.1









Mg2+, Co2+ transporter, MgtE (Smith et al. 1995).

Bacteria
Firmicutes
MgtE of Bacillus firmus (Q45121)
*1.A.26.1.2









The Mg2+ transporter, MgtE. The crystal structure of the N-terminal hydrophilic domain has been determined to 2.3 Å resolution (Hattori et al., 2007) (>50% identical to 9.A.19.1.1), while the C-terminal transmembrane domain has been determined at 2.2 Å resolution (Takeda et al. 2014). The structure reveals a homoldimer with the channel at the interface of the two subunits.  There's a plug at the cytoplasmic face.  It can bind Mg2+, Mn2+ and Ca2+.

Bacteria
Deinococcus-Thermus
MgtE of Thermus thermophilus (Q5SMG8)
*1.A.26.1.3









The MgtE Mg2+ transporter.  Its expression can compensate a TrpM7 deficiency in vertebrate B-cells (Sahni et al. 2012).

Bacteria
Firmicutes
MgtE of Bacillus subtilis
*1.A.26.1.4









Mg2+, Co2+ transporter, MgtE

Bacteria
Proteobacteria
MgtE of Providencia stuartii (Q52398)
*1.A.26.1.5









MgtE homologue (function unknown)

Archaea
Euryarchaeota
MgtE homologue of Methanobacterium thermoautotrophicum (O26717)
*1.A.26.1.6









MgtE homologue of 469 AAs and 5 OR 6 TMSs (Pohland and Schneider 2019).

Bacteria
Cyanobacteria
MgtE of Prochlorococcus marinus
*1.A.26.2.1









Mg2+ transporter, SLC41A1 (10 TMSs; N- and C-termini inside) (Wabakken et al., 2003; Schmitz et al., 2007; Kolisek et al., 2008; Sponder et al. 2013). It has been reported to be a Na+:Mg2+ antiporter and therefore a Mg2+ efflux pump (Fleig et al. 2013).  Regulated by Mg2+-dependent endosomal recycling through its N-terminal cytoplasmic domain (Mandt et al., 2011).  Mutations result in a nephronophthisis (NPHP)-like ciliopathic phenotype (Hurd et al. 2013). Reviewed by Schäffers et al. 2018.

Eukaryota
Metazoa
SLC41A1 of Homo sapiens
*1.A.26.2.2









Mg2+ transporter, SLC41A2 (11 TMSs with the N-terminus out and the C-terminus in) (Sahni et al. 2007). (63% identical to SLC41A1) See also (Wabakken et al., 2003; Schmitz et al., 2007)

Eukaryota
Metazoa
SLC41A2 of Homo sapiens
*1.A.26.2.3









Solute carrier protein (SLC) 41A3.  The gene is upregulated when mice are given a Mg2+ deficient diet (de Baaij et al. 2013).  SLC41A3 knockout mice develop abnormal locomotor coordination. It is an established Mg2+ transporter involved in mitochondrial Mg2+ homeostasis (Schäffers et al. 2018).

Eukaryota
Metazoa
SLC41A3 of Homo sapiens
*1.A.26.2.4









MagT or MgtE of 503 aas and 12 TMSs in a 3 + 6 + 3 arrangement. According to CDD, the domain order is:  MgtE_N, a CBS pair (two repeats) and an MgtE domain.

Eukaryota
Metazoa
MagT of Caenorhabditis elegans
*1.A.26.3.1









MgtE of 251 aas and 5 TMSs

Archaea
Euryarchaeota
MgtE of Natrinema gari