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1.A.3.1.9
Ryanodine-sensitive Ca2+ release channel RyR1 of 5117 aas and 6 TMSs.  Diamide insecticides, such as flubendiamide and chlorantraniliprole, selectively activate insect ryanodine receptors. They are particularly active against lepidopteran pests of cruciferous vegetable crops, including the diamondback moth, Plutella xylostella. Resistance results from mutation(s) in the ryanodine receptors' transmembrane domain (Troczka et al. 2017).

Accession Number:G8EME3
Protein Name:Ryanodine receptor 1
Length:5117
Molecular Weight:578482.00
Species:Plutella xylostella (Diamondback moth) [51655]
Number of TMSs:6
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN IQDKNIPPDL 
61:	SQCVFVIEQA LSVRALQELV TAAGSETGKG TGSGHRTLLY GNAILLRHLN SDMYLACLST 
121:	SSSQDKLAFD VGLQEHSQGE ACWWTLHPAS KQRSEGEKVR VGDDLILVSV ATERYLHTTK 
181:	ENEVSIVNAS FHVTHWSVQP YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSSWSNEG 
241:	QHNIVVYEGG SVMSQARSLW RLELARTKWA GGFINWYHPM RIRHITTGRY LAVNDQNELY 
301:	LVSREEATTA SCAFCLRQEK DDQKVVLEDK DLEIIGAPII KYGDSTVIVQ HSESSLWLSY 
361:	KSYETKKKGL GKVEEKQAIL HEEGKMDGLD FSRSQEEESR TARVIRKCSS LFTKFINGLE 
421:	TLQENRRHSM FFATVNLAEM VMCLEDLINY FAQPDEDMEH EEKQNKFRAL RNRQDLFQEE 
481:	GILNLILEAI DKINVITSQG FLAGFLAGDE CGQSWEMISA YLYQLLAAII KGNHTNCAQF 
541:	ANSNRLNWLF SRLGSQASGE GTGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD 
601:	PKVLDVLCSL CVGNGVAVRS SQNNICDYLL PGKNLLLQTQ LVDHVSSVRP NIFVGRVEGS 
661:	AVYQKWYFEV TMDHIEKTTH MMPHLRIGWA NTTGYVPYPG GGEKWGGNGV GDDLYSYGYD 
721:	GAFLWSGGRK TGVNRTHAEE PYIRKGDVIG CALDLTVPII NFMFNGVRVT GSFTNFNLEG 
781:	MFFPVISCSS KLSCRFLLGG EHGRLRYAAP EGYSPLVECL LPQQILSLEP CFCFGNLAKR 
841:	ALSGPPLVQD DTAFVPMPVD TLTITLPSYI EQIRDKLAEN IHEMWAMNKI EAGWMYGEHR 
901:	ENLHKIHPCL VPFERLPAAE KRYDIQLAVQ TLKTILALGY YISLDKPPAR IRNVRLPNEP 
961:	FLQSNGYKPA PLDLSAVTLT PKMDELVEQL AENTHNLWAR ERIQQGWTYG LNEDSDMHRS 
1021:	PHLVPYPKVD EAIKKANRDT ASETVRTLLV YGYMLDPPTG EHEALLAEAS KMKQADFRTY 
1081:	RAEKNYAVNS GKWYFEFEIL TAGPMRVGWA HADMPPGMML GQDENSWAFD GYNEEKVYVN 
1141:	SSESFGKQWA VGDVVGVFLD LIDNTISFSL NGELLMDALG GETTFADVQG DNFVPACTLG 
1201:	VGRKARLTYG QDVNTLKYFT TCGLQEGYEP FCVNMKRDVT HWYTKDQPIF ENTDEMADTR 
1261:	IDVTRIPAGS ETPPCMKISH NTFETMEKAN WEFLRLSLPV ICHAEFIDEN EKARRWVEIK 
1321:	ERQQALMKEA AEAQMPAHID QIMRSGFTMN DIKGLHRDYD DGQEEPSNSK MKRLPSRPPR 
1381:	KGSLSRGVTI QNYSLQPGQQ NGMHRTASEM EMSKYESGAQ SVTDDKKDKR GRSPFKFFSR 
1441:	SKRGESGDRK SRKSKTPDPF SDAEVSPERA APRRPNPQIR VSQANQRYEK NQSRQNLYGS 
1501:	QGGGLNNGNT NLQVNTPPVE RKQMTGGALS GATTETVGNE IFDAECLKLI NEYFYGVRIF 
1561:	PGQDPTHVYI GWVTTQYHLH SKDFNQSKVT KSSVIITDDY DRVIRSVNRQ SCYMVRADEL 
1621:	YNEVMAEAVG KGASQGMFVG CSVDTSTGTV AFTCEGKETS FRFSMEPETK LFPAIFVEAT 
1681:	SKEILQIELG RSLHSLPLSA AVLPTSDKHV IPQFPPRLKV QCLKPHQWAR VPNQSLQVHA 
1741:	LKLSDIRGWS MLCEDAVSML ALHIPEEDRC IDILELIEMD KLLSFHSHTL TLYAALCYQS 
1801:	NYRAAHALCQ HVDQKQLLYA IQSQYMSGPL RQGFYDLLIA LHLESHATTM EVCKNEYVIP 
1861:	LGPELKALYE EPEMGHSLRS LQTESVRPMM KMTDIAESIN EISNLYSPYF PLEVVREFVM 
1921:	QALAEAVETN QVHNRDPVGG SNENLFLPLI KLVDRLLLVG MMRDEDVEKL LIMTNPETWD 
1981:	PTFDKEGKDE HKKGLLHMKM AEGAKLQMCY LLHHLNDIQL RHRVEAIIAF AHDFVGDLQA 
2041:	DQLRRYVEIK QSDLPSAVAA KKTREYRCPP REQMNAILSF KHLEEDDKEN IPCGEDLIAR 
2101:	MNDFHQALMA HVSLMALQEP EVEENPEALN KPGAIGKLYN IINTVKELDE EPKAIEEPVK 
2161:	KTPEEKFRKV LIQTIVSWAE ESQIETPKLV REMFSLLVRQ YDAVGELVRA LEKTYVINAK 
2221:	TKLDVAEMWV GLSQIRALLP VQMSQEEEEL MRKRLWKLVN NHTFFQHPDL IRVLRVHENV 
2281:	MAVMMNTLGR RAQAQSDATP NQPAAEEKDT SHEMVVACCR FPCYFCRTGR QNQKAMFDHF 
2341:	DFLLENSNIL LSRPSLRGST PLDVAYSSLM ENTELALALR EHYLEKIAVY LSRCGLQSNS 
2401:	ELVEKGYPDL GWDPVEGERY LDFLRFCVWV NGESVEENAN LVIRLLIRRP ECLGPALRGE 
2461:	GEGLLKAIVD ANKMSEKIAD RRKLHEEVGQ EDVAFSHPLP ESDEDEDYID TGAAILNFYC 
2521:	TLVDLLGRCA PDASVIALGK NESLRARAIL RSLVPLEDLQ GVLSLRFTLN NPAMGEERPK 
2581:	SDMPSGLIPG HKQSIVLFLE RVYGIETQEL FYRLLEEAFL PDLRAATMLD RNDGCESDMA 
2641:	LSMNRYIGNS ILPLLIKHAN FYNEAENYGS LLDATLHTVY RLSKNRMLTK GQREAVSDFL 
2701:	VALTSAMQPS HVAETAEETH GDVSKLSEYT TVALRLLTLH YERCAKYYGS TGGQGVYGAS 
2761:	SDEEKRLTMM LFSNIFDSLS KMDYEPELFG KALPCLIAIG CALPPDYSLS KNYDDEFYGK 
2821:	EQQTTGGPDN PQYNPQPINT SSVALNNDLN TIVQKFSEHY HDAWASRKIE NSWVYGENWS 
2881:	DSQKAHPRLK PYNMLNDYEK ERYKEPVRES LKALLAIGWS VEHSEVDIPS TNRSSMRRQS 
2941:	KSGGRPVDVV TDSATPFNYN PHPVDMTNLT LSREMQNMAE RLAENAHDIW AKKKKEELTV 
3001:	NGGGIHPQLV PYDLLTDKEK KKDRERSQEF LKYLQYQGYK LHRPSKATQS ETEQTATGVA 
3061:	IELRFAYSLL EKLIQYIDRA TINMKMLKPS TTFSRRSSFK TSTRDIKFFS KVVLPLMEKY 
3121:	FSTHRNYFIA VATATNNVGA ASLKEKEMVA ALFCKLASLL RSRLTAFGPD VRITVRCLQV 
3181:	LVKGIDAKSL VKNCPEFIRT SMLTFFNNVA DDLGHTIHYL QDGKYSHLRG THLKTSTSLG 
3241:	YINGVIMPVL TAMFDHLANC EYGADLLLDE IQVASYKMLG SLFTLGTDST LTHDRKYLKT 
3301:	EIERHKNALG SCLGAFSSTF PVAFLKPHLN KHNQFSLLNR IADHSLEAQD VMARMEQSMP 
3361:	TLETILGLVE QFVDSDKTYS DSPHVIDVVL PLLCSYLPFW WAQGPDNVTP SGGNHVTMVT 
3421:	ADHMNQLLKN VLKLIKKNIG NENAPWMTRI ATYAQQIIIN SSEELLRESF LPLAERVRKR 
3481:	TDNMFHKEES LRGFIKSSTD DTSQVESQIQ EDWQLLVRDI YSFYPLLIKY VDLQRNHWLR 
3541:	NNVNEAEELY NHVAEIFNIW SKSQYFFKEE QNFISANEID NMVLIMPTAT RRVTTVVDGA 
3601:	PQGGGKVKKK KKHRDKKRDK DKEVQASLMV ACLKRLLPVG LNLFAGREQE LVQHCKDRFL 
3661:	KKMTEQDVAE FAKTQLTLPD KIDPADEMSW QHYLYSKLGS KSKTTTAMET AAENKAKIID 
3721:	DTVERIVAMS KVLFGLHMID HPQQMSKNVY RSVVSIQRKR AVIACFRHLP LHQLPRHRAC 
3781:	NIFSRTYYEL WLEEENIGQE VMIEDLTQSF EDAELKKSDV EAEGEGKPDP LTQLVTTFCR 
3841:	GAMTERSGAL QEDPLCMSYA HIIAKSCGEE EEEGGEEEEE GAGEAEGEEE GGASIHEQEM 
3901:	EKQKLLFHQA RLADRGVAEM VLLHISASKG VPSDMVMKTL QLGISILRGG NIDIQMGMLN 
3961:	HLKDKKDVGF FTSIAGLMNS CSVLDLDAFE RNTKAEGLGV GLEGAAGEKN MHDAEFTCAL 
4021:	FRFIQLTCEG HNLEWQNYLR TQAGNTTTVN VVICTVDYLL RLQESIMDFY WHYSSKELID 
4081:	PAGKANFFKA IGVASQVFNT LTEVIQGPCT QNQQALAHSR LWDAVGGFLF LFSHMQDKLS 
4141:	KHSSQVDLLK ELLNLQKDMI TMMLSMLEGN VVNGTIGKQM VDTLVESASN VELILKYFDM 
4201:	FLKLKDLTTS ASFAEIDANN DGWVLPKDFK EKMEQQKSYT PEEIEFLLAC CETNHDGKLD 
4261:	YIGFCDRFHE PAKEIGFNLA VLLTNLSEHM PNEPRLARFL ETAGSVLNYF EPFLGRIEIM 
4321:	GGSKRIERVY FEIKESNIEQ WEKPQIKESK RAFFYSIVTE GGDKEKLEAF VNFCEDAIFE 
4381:	MTHASGLMAD AEEAGGGPKN REAAYMYMGD DDDDSRGKDP FRRGLQSVKD GIATAFSSLS 
4441:	PANMKQKIAD MSQMPPQELA VGFFKMFFYL FYYIGYGALV VVRYIFGVLL GLMRGPQVEE 
4501:	PPPEPTEEEK IGPSRHLPAL SATDDQGQMA VSAFGLDITK EDNGQVQIKP HESPGTSSPS 
4561:	SGEEAETAED GEHSGDEPQP PSLIDLLGGE QAKKQAQERI EAQAAQQAAM SAIEAESKKA 
4621:	VQAPAPSALS QVDLSQYTRR AVSFLARKFY TLKYVALVLA FCINFVLLFY KVSTLDAEPG 
4681:	EGSGIGDIIS GSGSGSGSGS GDGGSGEEDE DPIELVHIDE DYFYMEHVIK IAALLHSIVS 
4741:	LAILIGYYHL KVPLAIFKRE KEIARKLEFD GLYIAEQPED DDLKSHWDKL VISAKSFPVN 
4801:	YWDKFVKKKV RAKYSETYDF DSISNMLGME KTAFATQEDE GRGFFHYILS IDWRYQVWKA 
4861:	GVTITDNSFL YSLWYFSFSV MGNFNHFFFA AHLLDVAVGF KTLRTILQSV THNGKQLVLT 
4921:	VMLLTIIVYI YTVIAFNFFR KFYVQEEDDD INRNCHDMLT CFVFNLYKGV RAGGGIGDEL 
4981:	EPPDGDDSEA WRIVFDITFF FFIIVILLAI LQGLIIDAFG ELRDQLESVK EDMESNCFIC 
5041:	GINKDYFDKV PHGFDTHVQR EHNLANYMFF LMHLINKPDT EYTGQETYVW NMYTQRCWDF 
5101:	FPVGDCFRKQ YEDAMGE