TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.31.1.1









Annexin X
Eukaryota
Metazoa
Annexin X of Drosophila melanogaster
*1.A.31.1.2









Annexin VI
Eukaryota
Metazoa
Annexin VI of Homo sapiens (673 aas; P08133)
*1.A.31.1.3









Annexin A1 (McNeil et al., 2006)

Eukaryota
Metazoa
Annexin A1 of Homo sapiens (346 aas; P04083)
*1.A.31.1.4









Annexin 2 or Annexin A2 (ANXA2) of 339 aas.  Forms a tetrameric complex with the S100A10 protein and binds the C-terminus of the AHNAK protein via the N-terminus of annexin 2 (De Seranno et al., 2006). Direct translocation of Annexin 2 to the cell surface occurs by pore-formation.  External annexin A2 acts as a plasminogen receptor, able to stimulate fibrinolysis and cell migration (Pompa et al. 2017).

Eukaryota
Metazoa
Annexin 2 of Homo sapiens
*1.A.31.1.5









Non-selective cation channel-forming annexin 1 of 313 aas, Ann1 (Kodavali et al. 2013).

Eukaryota
Viridiplantae
Ann1 of Medicago truncatula
*1.A.31.1.6









Annexxin of 369 aas.  Schistosomiasis, a major parasitic disease of humans, is second only to malaria in its global impact. The disease is caused by digenean trematodes that infest the vasculature of their human hosts. These flukes are limited externally by a body wall composed of a syncytial epithelium, the apical surface membrane, a parasitism-adapted dual membrane complex. Annexins are important for the stability of this apical membrane system. Leow et al. 2013 presented the first structural and immunobiochemical characterization of an annexin from Schistosoma mansoni. The crystal structures of annexin B22 (4MDV and 4MDU) in the apo and Ca2+ bound forms confirmed the presence of the previously predicted α-helical segment in the II/III linker and revealed a covalently linked head-to-head dimer. The dimeric arrangement revealed a non-canonical membrane binding site and a probable binding groove opposite the binding site. Annexin B22 expression correlated with life stages of the parasite that possess the syncytial tegument layer, and ultrastructural localization by immuno-electron microscopy confirmed the occurrence of annexins in the tegument of S. mansoni.

Eukaryota
Metazoa
Annexin B22 of Schistosoma mansoni
*1.A.31.1.7









Annexin A5 of 320 aas. Annexin A5 (ANXA5), a Ca2+ and phospholipid binding protein, interacts with the N-terminal leucine-rich repeats of polycystin-1 (TC# 1.A.5.1.2). This interaction is direct and specific, and involves a conserved sequence of the ANXA5 N-terminal domain (Markoff et al. 2007).

Eukaryota
Metazoa
Annexin A5 of Homo sapiens