TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.33.1.1









Heat shock cognate 70 kDa protein, Hsc70
Eukaryota
Viridiplantae
Hsc70 of Arabidopsis thaliana
*1.A.33.1.2









Heat shock protein-70 homologue, DnaK.  A transport function in eukaryotes, but not prokaryotes has been demonstrated.

Bacteria
Proteobacteria
DnaK of E. coli
*1.A.33.1.3









Heat shock protein 70(1B)
Eukaryota
Metazoa
Hsp70(1B) of Homo sapiens (AAH57397)
*1.A.33.1.4









DnaK of 611 aas

Bacteria
Firmicutes
DnaK of Bacillus subtiiis
*1.A.33.1.5









Hsp70 homologue

Bacteria
Spirochaetes
Hsp70 homologue of Leptospira interrogans
*1.A.33.1.6









Glucose regulated protein, GRP78 of 654 aas.  GRP78, a member of the ER stress protein family.  It can relocate to the surface of cancer cells, playing a role in promoting cell proliferation and metastasis. GRP78 consists of two major functional domains: the ATPase and protein/peptide-binding domains. The protein/peptide-binding domain of cell-surface GRP78 has served as a novel functional receptor for delivering cytotoxic agents (e.g., a apoptosis-inducing peptide or taxol) across the cell membrane. The ATPase domain of GRP78 (GRP78ATPase) has potential as a transmembrane delivery system of cytotoxic agents including nucleotides (e.g., ATP-based nucleotide triphosphate analogs) (Hughes et al. 2016). May also play a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum (Evensen et al. 2013). It is involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (Evensen et al. 2013).

Eukaryota
Metazoa
*1.A.33.2.1









MMAR_0617 MOMP (Hsp70 homologue) (van der Woude et al. 2013).

Bacteria
Actinobacteria
MMAR_0617 of Mycobcterium marinum
*1.A.33.2.2









Hsp70 homologue of 581 aas.

Bacteria
Actinobacteria
Hsp70 homologue of Mycobacterium tuberculosis
*1.A.33.2.3









Hsp70 homologue of 455 aas

Bacteria
Actinobacteria
Hsp70 of Nocardia farcinica