TCDB is operated by the Saier Lab Bioinformatics Group


1.A.36 The Intracellular Chloride Channel (ICC) Family

Mammals possess an intracellular (endoplasmic reticular, Golgi and nuclear membrane) protein which in humans is 551 aas long and exhibits 3 - 5 TMSs. Homologues have been identified in rodents and frogs (see 1.A.36.1.5), but not in C. elegans or D. melanogaster. The protein has been shown to exhibit anion-selective channel activity (Nagasawa et al., 2001). Although it was isolated using a yeast MID1 gene mutant (see TC # 1.A.16), it does not exhibit appreciable sequence similarity to the yeast Mid1 protein. Of the 4 putative TMSs, TMSs 1 and 4 are strongly hydrophobic while TMSs 2 and 3 are only weakly hydrophobic. None is strongly amphipathic when the angle is set at 100° as is appropriate for an α-helix.


References associated with 1.A.36 family:

Al Khamici, H., L.J. Brown, K.R. Hossain, A.L. Hudson, A.A. Sinclair-Burton, J.P. Ng, E.L. Daniel, J.E. Hare, B.A. Cornell, P.M. Curmi, M.W. Davey, and S.M. Valenzuela. (2015). Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity. PLoS One 10: e115699. 25581026
Basham, S.E. and L.S. Rose. (1999). Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos. Dev Biol 215: 253-263. 10545235
Giannotta, M., G. Fragassi, A. Tamburro, C. Vanessa, A. Luini, and M. Sallese. (2015). Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling. Biomed Res Int 2015: 319454. 26064897
Jia, Y., T.J. Jucius, S.A. Cook, and S.L. Ackerman. (2015). Loss of Clcc1 Results in ER Stress, Misfolded Protein Accumulation, and Neurodegeneration. J. Neurosci. 35: 3001-3009. 25698737
Leanza, L., L. Biasutto, A. Managò, E. Gulbins, M. Zoratti, and I. Szabò. (2013). Intracellular ion channels and cancer. Front Physiol 4: 227. 24027528
Nagasawa, M., M. Kanzaki, Y. Iino, Y. Morishita, and I. Kojima. (2001). Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. J. Biol. Chem. 276: 20413-20418. 11279057
Pichler, S., P. Gönczy, H. Schnabel, A. Pozniakowski, A. Ashford, R. Schnabel, and A.A. Hyman. (2000). OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos. Development 127: 2063-2073. 10769231