TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.37.1.1









The CD20 cation channel (B-lymphocyte CD20 antigen)
Eukaryota
Metazoa
CD20 of Homo sapiens
*1.A.37.2.1









Membrane-spanning 4 TMS subfamily A member 10 (MS4A superfamily), HTm4

Eukaryota
Metazoa
HTm4 of Homo sapiens (Q96PG2)
*1.A.37.3.1









4 TMS testes development-related NYD-SP21 protein

Eukaryota
Metazoa
NYD-SP21 of Homo sapiens (Q96JA4)
*1.A.37.3.2









MS4A2 of 244 aas and 4 TMSs. High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of Fc epsilon receptor (FCERI) by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines (Penhallow et al. 1995). Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

MS412 of Homo sapiens
*1.A.37.4.1









Fam189A1 or CD20 family with 539 aas and 4 TMSs.

Eukaryota
Metazoa
CD20 family protein of Homo sapiens
*1.A.37.5.1









Sarcospan, SSPN, of 242 aas and 4 TMSs.  Part of the smooth muscle sarcoglycan-sarcospan  complex which in involved in idiopathic cardiomyopathy associated with myocardial ischemia (Cohn et al. 2001).  Regulated by astroglial connexin 30 channels (TC# 1.A.24.1.7; Boulay et al. 2015).

Eukaryota
Metazoa
Sarcospan of Bos taurus
*1.A.37.6.1









TMem196 of 185 aas and 4 TMSs,  Acts as a tumor suppressor (Liu et al. 2015).

Eukaryota
Metazoa
TMem196 protein of Canis lupus familiaris (Dog) (Canis familiaris)
*1.A.37.7.1









Transmembrane protein 212, TMEM212, of 194 aas and 4 or 5 TMSs (Brown et al. 2012).

Eukaryota
Metazoa
TMEM212 of Homo sapiens