| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
*1.A.37.1.1 | The CD20 cation channel (B-lymphocyte CD20 antigen) | Eukaryota |
Metazoa | CD20 of Homo sapiens |
|
*1.A.37.1.5 | Uncharacterized protein of 247 aas and 4 TMSs in a 3 + 1 TMS arrangement. | Eukaryota |
Metazoa | UP of Xiphophorus couchianus (Monterrey platyfish) |
|
*1.A.37.2.1 | Membrane-spanning 4 TMS subfamily A member 10 (MS4A superfamily), HTm4 | Eukaryota |
Metazoa | HTm4 of Homo sapiens (Q96PG2) |
|
*1.A.37.3.1 | 4 TMS testes development-related NYD-SP21 protein | Eukaryota |
Metazoa | NYD-SP21 of Homo sapiens (Q96JA4) |
|
*1.A.37.3.2 | MS4A2 of 244 aas and 4 TMSs. High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of Fc epsilon receptor (FCERI) by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines (Penhallow et al. 1995). Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. | MS412 of Homo sapiens | ||
|
*1.A.37.3.3 | Uncharacterized membrane-spanning 4-domain subfamily A member 4A-like protein of 261 aas and 4 or 5 TMSs in a 3 or 4 + 1 TMS arrangement. | Eukaryota |
Metazoa | UP of Cyprinus carpio |
|
*1.A.37.4.1 | Fam189A1 or CD20 family with 539 aas and 4 TMSs. | Eukaryota |
Metazoa | CD20 family protein of Homo sapiens |
|
*1.A.37.5.1 | Sarcospan, SSPN, of 242 aas and 4 TMSs. Part of the smooth muscle sarcoglycan-sarcospan complex which in involved in idiopathic cardiomyopathy associated with myocardial ischemia (Cohn et al. 2001). Regulated by astroglial connexin 30 channels (TC# 1.A.24.1.7; Boulay et al. 2015). | Eukaryota |
Metazoa | Sarcospan of Bos taurus |
|
*1.A.37.6.1 | TMem196 of 185 aas and 4 TMSs, Acts as a tumor suppressor (Liu et al. 2015). | Eukaryota |
Metazoa | TMem196 protein of Canis lupus familiaris (Dog) (Canis familiaris) |
|
*1.A.37.7.1 | Transmembrane protein 212, TMEM212, of 194 aas and 4 or 5 TMSs (Brown et al. 2012). | Eukaryota |
Metazoa | TMEM212 of Homo sapiens |
|
*1.A.37.8.1 | TMEM176B of 270 aas and 4 - 6 TMSs. It is upregulated in Meniere's disease (Sun et al. 2018). Phylogenetic analyses of the MS4A and TMEM176 gene families have been reported (Zuccolo et al. 2010). This protein is up-regulated in Meniere's disease (Sun et al. 2018). | Eukaryota |
Metazoa | TMEM176B of Homo sapiens |
|
*1.A.37.8.2 | TMEM176A of 235 aas and 4 to 6 TMSs in a 3 or 4 TMS cluster followed by a 1 or 2 TMS cluster. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma due to promoter methylation (Li et al. 2018). | Eukaryota |
Metazoa | TMEM176A of Homo sapiens |
|
*1.A.37.8.3 | Uncharacterized protein of 244 aas and 5 TMSs in a 4 + 1 TMS arrangement. | Eukaryota |
Metazoa | UP of Carassius auratus |
|
*1.A.37.8.4 | Uncharacterized TMEM176 homologue of 326 aas and an apparent 4 TMSs in a 3 + 1 TMS arrangement with a C-terminal annexin domain (see TC# 1.A.31). | Eukaryota |
Metazoa | UP of Branchiostoma floridae (Florida lancelet) (Amphioxus) |
