TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.37.1.1









The CD20 cation channel (B-lymphocyte CD20 antigen)
Eukaryota
Metazoa
CD20 of Homo sapiens
*1.A.37.1.5









Uncharacterized protein of 247 aas and 4 TMSs in a 3 + 1 TMS arrangement.

Eukaryota
Metazoa
UP of Xiphophorus couchianus (Monterrey platyfish)
*1.A.37.2.1









Membrane-spanning 4 TMS subfamily A member 10 (MS4A superfamily), HTm4

Eukaryota
Metazoa
HTm4 of Homo sapiens (Q96PG2)
*1.A.37.3.1









4 TMS testes development-related NYD-SP21 protein

Eukaryota
Metazoa
NYD-SP21 of Homo sapiens (Q96JA4)
*1.A.37.3.2









MS4A2 of 244 aas and 4 TMSs. High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of Fc epsilon receptor (FCERI) by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines (Penhallow et al. 1995). Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

MS412 of Homo sapiens
*1.A.37.3.3









Uncharacterized membrane-spanning 4-domain subfamily A member 4A-like protein of 261 aas and 4 or 5 TMSs in a 3 or 4 + 1 TMS arrangement.

Eukaryota
Metazoa
UP of Cyprinus carpio
*1.A.37.4.1









Fam189A1 or CD20 family with 539 aas and 4 TMSs.

Eukaryota
Metazoa
CD20 family protein of Homo sapiens
*1.A.37.5.1









Sarcospan, SSPN, of 242 aas and 4 TMSs.  Part of the smooth muscle sarcoglycan-sarcospan  complex which in involved in idiopathic cardiomyopathy associated with myocardial ischemia (Cohn et al. 2001).  Regulated by astroglial connexin 30 channels (TC# 1.A.24.1.7; Boulay et al. 2015).

Eukaryota
Metazoa
Sarcospan of Bos taurus
*1.A.37.6.1









TMem196 of 185 aas and 4 TMSs,  Acts as a tumor suppressor (Liu et al. 2015).

Eukaryota
Metazoa
TMem196 protein of Canis lupus familiaris (Dog) (Canis familiaris)
*1.A.37.7.1









Transmembrane protein 212, TMEM212, of 194 aas and 4 or 5 TMSs (Brown et al. 2012).

Eukaryota
Metazoa
TMEM212 of Homo sapiens
*1.A.37.8.1









TMEM176B of 270 aas and 4 - 6 TMSs.  It is upregulated in Meniere's disease (Sun et al. 2018). Phylogenetic analyses of the MS4A and TMEM176 gene families have been reported (Zuccolo et al. 2010). This protein is up-regulated in Meniere's disease (Sun et al. 2018).  Pharmacologic de-repression of the inflammasome by targeting TMEM176B may enhance the therapeutic efficacy of immune checkpoint blockers (Segovia et al. 2019).

Eukaryota
Metazoa
TMEM176B of Homo sapiens
*1.A.37.8.2









TMEM176A of 235 aas and 4 to 6 TMSs in a 3 or 4 TMS cluster followed by a 1 or 2 TMS cluster. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma due to promoter methylation (Li et al. 2018).

Eukaryota
Metazoa
TMEM176A of Homo sapiens
*1.A.37.8.3









Uncharacterized protein of 244 aas and 5 TMSs in a 4 + 1 TMS arrangement.

Eukaryota
Metazoa
UP of Carassius auratus
*1.A.37.8.4









Uncharacterized TMEM176 homologue of 326 aas and an apparent 4 TMSs in a 3 + 1 TMS arrangement with a C-terminal annexin domain (see TC# 1.A.31).

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)