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1.A.37.8.1
TMEM176B of 270 aas and 4 TMSs in a 3 + 1 TMS arrangement.  It is upregulated in Meniere's disease (Sun et al. 2018). Phylogenetic analyses of the MS4A and TMEM176 gene families have been reported (Zuccolo et al. 2010).  Pharmacologic de-repression of the inflammasome by targeting TMEM176B may enhance the therapeutic efficacy of immune checkpoint blockers (Segovia et al. 2019). Inflammasome activation may reinforce anti-tumor immunity by boosting CD8(+) T cell priming as well as by enhancing T helper type 17 (Th17) responses. The modulation of the cation channel transmembrane protein 176B (TMEM176B) provides one such mechanis, and this protein privides a potential target to unleash inflammasome activation, leading to reinforced anti-tumor immunity and improved efficacy of immune checkpoint blockers (Segovia et al. 2020).

Accession Number:Q3YBM2
Protein Name:Transmembrane protein 176B
Length:270
Molecular Weight:29056.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Nucleus membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTQNTVIVNG VAMASRPSQP THVNVHIHQE SALTQLLKAG GSLKKFLFHP GDTVPSTARI 
61:	GYEQLALGVT QILLGVVSCV LGVCLSLGPW TVLSASGCAF WAGSVVIAAG AGAIVHEKHP 
121:	GKLAGYISSL LTLAGFATAM AAVVLCVNSF IWQTEPFLYI DTVCDRSDPV FPTTGYRWMR 
181:	RSQENQWQKE ECRAYMQMLR KLFTAIRALF LAVCVLKVIV SLVSLGVGLR NLCGQSSQPL 
241:	NEEGSEKRLL GENSVPPSPS REQTSTAIVL