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1.A.37.8.2
TMEM176A of 235 aas and 4 to 6 TMSs in a 3 or 4 TMS cluster followed by a 1 or 2 TMS cluster. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma due to promoter methylation (Li et al. 2018).

Accession Number:Q96HP8
Protein Name:Transmembrane protein 176A
Length:235
Molecular Weight:26116.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGTADSDEMA PEAPQHTHID VHIHQESALA KLLLTCCSAL RPRATQARGS SRLLVASWVM 
61:	QIVLGILSAV LGGFFYIRDY TLLVTSGAAI WTGAVAVLAG AAAFIYEKRG GTYWALLRTL 
121:	LTLAAFSTAI AALKLWNEDF RYGYSYYNSA CRISSSSDWN TPAPTQSPEE VRRLHLCTSF 
181:	MDMLKALFRT LQAMLLGVWI LLLLASLTPL WLYCWRMFPT KGKRDQKEML EVSGI