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1.A.4.5.13
TRPM8 of the collared flycatcher of 1103 aas.  It is 83% identical to the human ortholog. Its structure has been determined to ~4.1 Å resolution by cryo EM (Yin et al. 2018). The structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer. The structure suggests that the menthol-binding site is located within the voltage-sensor-like domain and thus provides a structural glimpse of the design principle of the molecular transducer for cold and menthol sensation (Yin et al. 2018).

Accession Number:U3JD03
Protein Name:Transient receptor potential cation channel subfamily M member 8
Length:1103
Molecular Weight:127545.00
Species:Ficedula albicollis (Collared flycatcher) [59894]
Number of TMSs:8
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	TLFQVSMGSM RHRRNGNFES SRLLYSSMSR SIDVACSDAD LANFIQENFK KRECVFFTKD 
61:	TKSMGNLCKC GYPENQHIEG TQVNTTEKWN YKKHTKELPT DAFGDIQFEN LGKRGKYIRL 
121:	SCDTDSETLY DLMTQHWHLK TPNLVISVTG GAKNFALKPR MRKIFSRLIY IAQSKGAWIF 
181:	TGGTHYGLMK YIGEVVRDNT ISRSSEENVV AIGIAAWGMI SNRETLIRTA DSDGSYLAHY 
241:	IMDDLKRDPL YCLDNNHTHL LLVDNGTHGH PTIEAKVRTQ LEKYISERVI PESNYGGKIP 
301:	IVCFAQGGGK ETLKSINVAI KSKIPCVVVE GSGRIADVIA SLVEAEGTLA SSCVKESLLR 
361:	FLPRTISRLS EEETESWIKW IKEVLESPHL LTVIKIEEAG DEIVSNAISF ALYKAFSTNE 
421:	HDRDNWNGQL KLLLEWNQLD LASDEIFTND RNWESADLQD VMFTALVKDR PKFVRLFLEN 
481:	GLNLRKFLTT EVLRELYTNN FSSLVFKNLQ IAKNSYNDAL LTFVWKMVED FRRGFKRYYK 
541:	NSKDEMEIEL SEECPITRHP LQALFIWSVL QNKKELSKVI WEQTRGCTLA ALGASKLLKS 
601:	MAKVKNDINA AGESEELANE YETRAVELFT ECYSNDEDLA EQLLTYSCEA WGGSNCLELA 
661:	VEARDQQFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF FFPLIGCGFI SFRKKPVEKT 
721:	KKLFLYYVSF FTSPFVVFSW NVIFYIAFLL LFAYVLLMDF QKEPTALEII LYVLVFILLC 
781:	DEVRQWYMNG SKYFSDLWNV MDTLAIFYFI AGIVFRLHSD ESSWYSGRVI FCLDYIVFTL 
841:	RLIHIFTVSR NLGPKIIMLQ RMMIDVFFFL FLFAVWMVAF GVARQGILRK NEHRWEWIFR 
901:	SVIYEPYLAM FGQYPDDIDG TTYNFDHCTF SGNESKPLCV ELDANNQPRF PEWITIPLVC 
961:	IYMLSTNILL VNLLVAMFGY TVGSVQENND QVWKFQRFFL VQEYCSRLTI PFPFVIFAYI 
1021:	FMVMRKCFKC CCKKESKEPS VCCSRNEDNE ILAWEAVMKE NYLVKINTKA SDSSEEMVHR 
1081:	FRQLDAKLSD LKGLLKEISS KIK