TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.40.1.1









The ion channel viral protein U, Vpu. The mutation A18H converts a non-specific channel to a selective proton channel that is sensitive to rimantadine (Sharma et al., 2011).  Vpu forms stable pentamers (Padhi et al. 2013).  The mechanism of Vpu, a weakly conducting cation-selective channel that assists in detachment of the virion from infected cells, has been proposed (Padhi et al. 2014).  Interactions of Vpu with host cellular constituents have been reviewed (González 2015). Vpu forms large homo aggregates of 16 or 32 subunits (Lin et al. 2016).

Viruses
Retroviridae
Vpu of HIV-1
*1.A.40.1.2









Vpu protein of 81 aas and 1 TMS.

Viruses
Retroviridae
Vpu of HIV1
*1.A.40.2.1









Simian immunodeficiency virus (SIV) Vpu of 79 aas and 1 TMS.

Viruses
Retroviridae
Vpu of Simian immunodeficiency virus (SIV)
*1.A.40.2.2









Simian immunodeficiency virus (SIV) Vpu protein of 83 aas and 1 TMS

Viruses
Retroviridae
Vpu of Simian immunodeficiency virus (SIV)
*1.A.40.2.3









Simian immunodeficiency virus (SIV) Vpu of 79 aas and 1 TMS.

Viruses
Retroviridae
Vpu of Simian immunodeficiency virus (SIV)
*1.A.40.2.4









Vpu of 85 aas and 1 TMS of Human immunodeficiency virus 1

Viruses
Retroviridae
Vpu of Human immunodeficiency virus 1