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1.A.42.1.1
Vpr of HIV

Accession Number:P12520
Protein Name:VPR
Length:96
Molecular Weight:11379.00
Species:Human immunodeficiency virus type 1 (New York-5 isolate) (HIV-1) [11698]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Virion1
Substrate Condensed DNA

Cross database links:

Pfam: PF00522   

Gene Ontology

GO:0005829 C:cytosol
GO:0043655 C:extracellular space of host
GO:0042025 C:host cell nucleus
GO:0005758 C:mitochondrial intermembrane space
GO:0019012 C:virion
GO:0005216 F:ion channel activity
GO:0006915 P:apoptosis
GO:0007049 P:cell cycle
GO:0019059 P:initiation of viral infection
GO:0044419 P:interspecies interaction between organisms
GO:0006811 P:ion transport
GO:0019047 P:provirus integration
GO:0045449 P:regulation of transcription
GO:0006350 P:transcription

References (4)

[1] “Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.”  Piller S.C.et.al.   8552585
[2] “Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1.”  Wang L.et.al.   8921884
[3] “Solution structure of peptides from HIV-1 Vpr protein that cause membrane permeabilization and growth arrest.”  Yao S.et.al.   9851370
[4] “Structure of human immunodeficiency virus type 1 Vpr(34-51) peptide in micelle containing aqueous solution.”  Engler A.et.al.   12084067
Structure:
1BDE   1DSJ   1DSK   1KZS   1KZT   1KZV   5JK7     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MEQAPEDQGP QREPYNEWTL ELLEELKSEA VRHFPRIWLH NLGQHIYETY GDTWAGVEAI 
61:	IRILQQLLFI HFRIGCRHSR IGVTRQRRAR NGASRS