TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.53.1.1









HCV-P7 (Clarke et al., 2006).  It's mechanism and  function have been investigated in considerable detail (Gan et al. 2014).  Histidine-17, which faces the lumen of the pore when protonated, allows Cl- entry, but deprotonation also allows Ca2+ entry.  Imposition of voltage creates a Cl- current (Wang et al. 2014). The structure and dual pore/ion channel activity of p7 of different HCV genotypes have been reviewed (Madan and Bartenschlager 2015). It may transport protons; it's structure has been determined by NMR (Montserret et al. 2010) and by electron microscopy (Luik et al. 2009).  The p7 N-terminal helical region is critical for E2/p7 processing, protein-protein interactions, ion channel activity, and infectious HCV production (Scull et al. 2015).

Viruses
Flaviviridae
P7 of hepatitis C virus (63 aas; 2 TMSs; CAH23613)
*1.A.53.1.2









p7 protein from the hepatitis C virus subtype 3a polyprotein.  Molecular interactions between NS2 and p7 and E2 have been observed, and the NS2 transmembrane region is required for both E2 interaction and subcellular localization. Specific mutations in core, envelope proteins, p7 and NS5A  abolish viral assembly (Popescu et al. 2011).

Viruses
Flaviviridae
p7 of hepatitis C virus subtype 3a
*1.A.53.1.3









Polyprotein containing p7 of hepacivirus AK.  Ion channel activity has been demonstrated in lipid bilayers (Walter et al. 2016).

Viruses
Flaviviridae
Polyprotein of hepacivirus AK
*1.A.53.1.4









CSFVA viroporin (70 aas; 2 TMSs). CSFV viroporin p7 protein induces IL-1β secretion which is inhibited by the ion channel blocker amantadine. The p7 protein is a short-lived protein degraded by the proteasome (Lin et al. 2014). CSFV-p7 forms pores wide enough to allow ANTS (MW, 427 Da) release. Two pore structures with slightly different sizes and opposite ion selectivities were detected (Largo et al. 2016). The relative abundances of these pore types depend on membrane composition suggesting that the physicochemical properties of the lipid bilayers present in the cell endomembrane system modulate viroporin activity.

Viruses
Flaviviridae
CSFVA P7 viroporin of Classical Swine Fever Virus (Q9YS30)
*1.A.53.1.5









The borine viral diarrhea virus (BVDV) p7 peptide, viral budding process initiator.

Viruses
Flaviviridae
p7 of Bovine viral diarrhea virus (AAB47140) polyprotein: Q96662 
*1.A.53.1.6









Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
Viruses
Flaviviridae
POLG_HCVVN of Hepatitis C virus genotype 6d
*1.A.53.1.7









Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
Viruses
Flaviviridae
POLG_HCVEU of Hepatitis C virus genotype 6a
*1.A.53.1.8









Hepatitis C virus p7 protein.  The NMR structure is available.  The channel is cation-selective and is inhibited by hexamethylene amiloride but not by amantadine.  The protein has an N-terminal α-helix that precedes TMS1, and TMSs 1 and 2 are connected by a long cytosolic loop bearing a dibasic motif (Montserret et al. 2010).

Viruses
Flaviviridae
p7 of Hepatitis C virus strain HCV-J (genotype 1b)
*1.A.53.1.9









Viroporin of 63 aas and 2 TMSs.

Viruses
Flaviviridae
Viroporin of Bovine viral diarrhea virus (BVDV) (Mucosal disease virus)