TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.56.1.1









Plasma membrane copper uptake transporter; takes up Cu2+ into the cytoplasm (Andrés-Colás et al. 2010).  Met-rich motifs in the N-terminal region, an MXXXM motif in TMS-2, and a GXXXG motif in TMS-3 could be essential for Cu transport since they are highly conserved in all analyzed species (Vatansever et al. 2016).

Eukaryota
Viridiplantae
CopT1 of Arabidopsis thaliana
*1.A.56.1.2









Copper (Cu+) and silver (Ag+) uptake transporter, Ctr1. The trimeric channel Eisses and Kaplan, 2005) forms an oligomeric pore with each subunit displaying 3 TMSs and 2 metal binding motifs (Lee et al., 2007). TMS2 is sufficient to form the trimer and the MXXM motif bind Ag+ (Dong et al. 2015). Ctr1 mediates basolateral uptakes of Cu+ in enterocytes (Zimnicka et al., 2007) and shows copper-dependent internalization and recycling which provides a reversible mechanism for the regulation of cellular copper entry (Molloy and Kaplan, 2009). It acts as a receptor for the two extinct viruses, CERV1 and CERV2 (Soll et al., 2010). Ctrl takes up platinum anticancer drugs, cisplatin and carboplatin (Du et al., 2012). The 3-d structure is known (Yang et al., 2012).  Ctr1 has a low turn over number of about 10 ions/second/trimer (Maryon et al. 2013).  Methionine and histidine residues in the transmembrane domain are essential for transport of copper, but when mutated, they stimulated uptake of cisplatin (Larson et al. 2010).  Plays important roles in the developing embryo as well as in adult ionic homeostasis (Wee et al. 2013). (-)-Epigallocatechin-3-gallate (EGCG), a major polyphenol from green tea, can enhance CTR1 mRNA and protein expression in ovarian cancer cells. EGCG inhibits the rapid degradation of CTR1 induced by cisplatin (cDDP). The combination of EGCG and cDDP increases the accumulation of cDDP and DNA-Pt adducts, and subsequently enhances the sensitivity of ovarian cancer (Wang et al. 2015). Steroid inhibitors may be able to overcome cycplatin resistance (Kadioglu et al. 2015).  Upregulated in colorectal cancer cells (Barresi et al. 2016).

Eukaryota
Metazoa
SLC31A1 or Ctr1 of Homo sapiens
*1.A.56.1.3









Vacuolar copper transporter (exports Cu+ from the vacuole to the cytoplasm; acts with Fre6 (Q12473: TC# 5.B.1.7.1) (metalo-reductase that reduces Cu2+ to Cu+ in the vacuole) (Rees and Thiele, 2007).
Eukaryota
Fungi
Ctr2p of Saccharomyces cerevisiae
*1.A.56.1.4









Copper uptake transporter
Eukaryota
Fungi
Ctr3p of Saccharomyces cerevisiae
*1.A.56.1.5









The heterodimeric high affinity copper uptake transporter, Ctr4/Ctr5. The Ctr4 central domain may mediate Cu2+ transport in this hetero-complex, whereas the Ctr5 carboxyl-terminal domain functions in the regulation of trafficking of the Cu2+ transport complex to the cell surface (Beaudoin et al., 2011).

Eukaryota
Fungi
Ctr4/Ctr5 of Schizosaccharomyces pombe
Ctr4
Ctr5
*1.A.56.1.6









Vacuolar, trimeric copper release protein (Beaudoin et al. 2013).

Eukaryota
Fungi
Ctr6 of Schizosaccharomyces pombe
*1.A.56.1.7









The CtrlB Copper transporter (expressed during late embryonic and larval stages of development in response to copper deprivation (Zhou et al., 2003).
Eukaryota
Metazoa
CtrlB of Drosophila melanogaster
(Q9VHS6)
*1.A.56.1.8









The plasma membrane copper import transporter, Ctr1A (3 isoforms in Drosophila, Ctr1A, 1B and 1C; Ctr1A but not Ctr1B is required for development) (Turski and Thiele, 2007)
Eukaryota
Metazoa
Ctr1A of Drosophila melanogaster (Q9W3X9)
*1.A.56.1.9









Probable low affinity copper uptake protein 2 (Ctr2) (present in the plasma membrane and interbal membranes where it stimulates copper uptake into the cytoplasm) (Bertinato et al., 2007; Wee et al. 2013).

Eukaryota
Metazoa
SLC31A2 of Homo sapiens
*1.A.56.1.10









The vacuolar copper transporter, Ctr2 (Involved in spore germination and pathogenesis (Barhoom et al., 2008))
Eukaryota
Fungi
Ctr2 of Colletotrichum gloeosporioides (A9XIK8)
*1.A.56.1.11









Vacuolar/tonoplast copper transporter 5 (AtCOPT5).  It exports copper from the vacuole to the cytoplasm and is required for photosynthetic electron transport under comditions of copper deficiency.  It also promotes interorgan allocation of copper (Garcia-Molina et al. 2011; Klaumann et al. 2011Klaumann et al. 2011).

Eukaryota
Viridiplantae
COPT5 of Arabidopsis thaliana
*1.A.56.1.12









Putative copper transporter 5.2 (OsCOPT5.2)
Eukaryota
Viridiplantae
COPT5.2 of Oryza sativa subsp. japonica
*1.A.56.1.13









Copper transporter 3 (OsCOPT3)
Eukaryota
Viridiplantae
COPT3 of Oryza sativa subsp. japonica
*1.A.56.1.14









Copper uptake system, COPT6. Interacts with itself and its homologue, COPT1. Regulated by copper availability by using SPL7 (Jung et al., 2012). 

Eukaryota
Viridiplantae
COPT6 of Arabidopsis thaliana (Q8GWP3)
*1.A.56.1.15









Copper transporter, PF14_0369 (Choveaux et al. 2012). Binds Cu+ and is present in both the erythrocyte and parasite plasma membranes (Choveaux et al. 2012).

Eukaryota
Apicomplexa
Copper transporter of Plasmodium falciparum
*1.A.56.1.16









Plasma membrane copper uptake channel of 257 aas, CtrC (Park et al. 2014).

Eukaryota
Fungi
CtrC of Neosartorya fumigata (Aspergillus fumigatus)
*1.A.56.1.17









Grape vacuolar copper transporter, Ctr1 (Martins et al. 2012).

Eukaryota
Viridiplantae
Ctr1 of Vitis vinifera
*1.A.56.1.18









Putative copper uptake transporter of 242 aas, CtrB (Park et al. 2014).

Eukaryota
Fungi
CtrB of Neosartorya fumigata (Aspergillus fumigatus)
*1.A.56.2.1









Plasma membrane high affinity copper transporter, Ctr1p (Puig et al., 2002); acts with Fre1 (P32791: TC# 5.B.1.5.1) (metalo-reductase that reduces Cu2+ to Cu+ at the cell surface (Rees and Thiele, 2007).
Eukaryota
Fungi
Ctr1p of Saccharomyces cerevisiae
*1.A.56.2.2









High affinity copper transporter, Ctr1p (Marvin et al., 2004)
Eukaryota
Fungi
Ctr1p of Candida albicans (CAB878806)
*1.A.56.3.1









Ctr1 assimilatory copper transporter (has a Cx2(Mx2)2 (C-x)5 motif) (Page et al. 2009).
Eukaryota
Viridiplantae
Ctr1 of Chlamydomonas reinhardtii (Q4U0V9)
*1.A.56.3.2









Copper uptake porter, CtrA2 (Park et al. 2014).

Eukaryota
Fungi
CtrA2 of Neosartorya fumigata (Aspergillus fumigatus)