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1.A.62.1.1
The homotrimeric monovalent cation channel, TRIC-A (Mitsugumin-33A; 298 aas; 3-6TMSs; DUF714 domain) (Yazawa et al., 2007). PK+:Na+ = 1.5; impermeable to divalent cations.

Accession Number:Q3TMP8
Protein Name:Transmembrane protein 38A aka TRIC-A
Length:298
Molecular Weight:33309.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Sarcoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate K+, Na+

Cross database links:

Genevestigator: Q3TMP8
eggNOG: roNOG13137
HEGENOM: HBG315839
RefSeq: NP_653117.1   
Entrez Gene ID: 74166   
Pfam: PF05197   
KEGG: mmu:74166   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031965 C:nuclear membrane
GO:0033017 C:sarcoplasmic reticulum membrane
GO:0015269 F:calcium-activated potassium channel activity
GO:0006813 P:potassium ion transport

References (3)

[1] “TRIC channels are essential for Ca2+ handling in intracellular stores.”  Yazawa M.et.al.   17611541
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDLMSALSLG ELALSFSRVP LFPVFDLSYF IVSIIYLKYE PGAVELSRRH PVASWLCAML 
61:	HCFGSYILAD LLLGEPIIDY FSNSSSILLA SGVWYLIFFC PLDLFYKCVC FLPVKLIFVA 
121:	MKEVVRVRKI AVGIHHAHHH YHHGWFIMIA TGWVKGSGVA LLSNVEQLLR GVWKPETNEI 
181:	LHMSFPTKAS LYGAILFTLQ QTRWLPVSKA SLIFVFTMFM VSCKVFLTAT HSHSSPFDIL 
241:	EGYICPVLFG ATWGGDHHHD NHGAPHGMGL GTQHSGLPAK AKEELGEGSR KKKTKKAD