TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.64.1.1









Channel-forming Plasmolipin (Fischer and Sapirstein, 1994)
Eukaryota
Metazoa
Plasmolipin of Rattus norvegicus (P47987)
*1.A.64.2.1









Myelin and Lymphocyte Protein, MAL/VIP17 protein, a regulator of NKCC2 (2.A.30.1.1). It stabilizes kidney apical membranes, and facilitates sorting of proteins to these membranes (Carmosino et al., 2010). Like plasmolipin, it has 4 TMSs that align with those of plasmolipin.

Eukaryota
Metazoa
MAL/VIP17 of Canis familiaris (Q28296)
*1.A.64.3.1









Myeloid-associated differentiation marker, MyADM (322 aas; 8 TMSs) 

Eukaryota
Metazoa
MyADM of Homo sapiens (Q96S97)
*1.A.64.4.1









4 TMS MARVEL superfamily member

Eukaryota
Metazoa
4TMS homologue of Caenorhabditis elegans (P83387)
*1.A.64.5.1









CKLF-like MARVEL transmembrane domain-containing protein 7, CMTM7 (175aas; 4 TMSs; Miyazaki et al., 2012). CMTM7 functions to link sIgM and BLNK in the plasma membrane, to recruit BLNK to the vicinity of Syk, and to initiate BLNK-mediated signal transduction (Miyazaki et al., 2012). No transport function is known.

Eukaryota
Metazoa
CMTM7 of Homo sapiens (Q96FZ5)
*1.A.64.5.2









Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein)

Eukaryota
Metazoa
  A4 protein of Homo sapiens
*1.A.64.5.3









Uncharacterized protein of 208 aas

Eukaryota
Metazoa
UP of Caenorhabditis elegans
*1.A.64.5.4









CKLF-like MARVEL transmembrane domain-containing protein 8 of 343 aas and 4 TMSs, CMTM8. A short splice variant, CMTM8-v2, retains the ability to induce apoptosis via caspase-dependent and -independent pathways to inhibit cell growth and colony formation. CMTM8 and CMTM8-v2 display different expression profiles and distinct subcellular localization patterns, while operating via different mechanisms to induce apoptosis. CMTM8-v2 does not affect EGFR internalization, implying that the MARVEL domain and/or the cytosolic YXXPhi motifs are necessary for CMTM8 to accelerate ligand-induced EGFR internalization (Li et al. 2007).

Eukaryota
Metazoa
CMTM8 of Anas platyrhynchos (Mallard) (Anas boschas)
*1.A.64.5.5









CKIF-like MARVEL transmembrane domain containing protein 1 of 169 aas and 4 TMSs, CMTM1.

Eukaryota
Metazoa
CMTM1 of Homo sapiens
*1.A.64.6.1









Marvel D3 tight junctionh-associated occludin of 401 aas and 4 TMSs; a determinant of paracellular permeability (Steed et al. 2009).

Eukaryota
Metazoa
MarvelD3 of Homo sapiens