TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.65.1.1









The E protein viroporin
Viruses
Nidovirales
E protein Viroporin of Murine Hepatitis Virus (MHV) (83aas; P0C2R0)
*1.A.65.1.2









The SARS coronavirus pore-forming envelope (E) protein (76 aas) (binds amantadine) (Torres et al., 2007). A single polar residue and distinct membrane topologies impact its function (Ruch and Machamer, 2012).  E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema accumulation and death.  Calcium ions together with pH modulated E protein pore charge and selectivity (Nieto-Torres et al. 2015). There is a single transmembrane domain in E, suggesting an allosteric interaction between extramembrane and transmembrane domains (To et al. 2016).

Viruses
Nidovirales
Protein E of SARS (NP_828854) (Q19QW7)
*1.A.65.1.3









Envelope small membrane viroporin protein of 82 aas and 1 TMS, protein E or sM.  Viroporin inhibitors have been identified (Takano et al. 2015).

Viruses
Nidovirales
Viroporin of feline infectious peritonitis virus (FIPV)
*1.A.65.1.4









MERS CoV Viroporin of 82 aas and 1 TMS.  Induces the formation of pentameric hydrophilic pores in cellular membranes followed by apoptosis (Surya et al. 2015).

Viruses
Nidovirales
Viroporin of Human Middle East respiratory syndrome coronavirus (MERS CoV) or EMC (HCoV-EMC)