TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.65.1.1









The envelope (E) viroporin protein of 85 aas and 2 TMSs.

Viruses
Nidovirales
E protein of Murine Hepatitis Virus (MHV) (83aas; P0C2R0)
*1.A.65.1.2









The SARS coronavirus pore-forming envelope (E) protein or protein 3a (76 aas; 1 TMS) forms a pentameric pore (Torres et al. 2006) that binds amantadine (Torres et al., 2007). A single polar residue and distinct membrane topologies impact its function (Ruch and Machamer, 2012).  The E protein ion channel (IC) activity is cation-specific and K+-selective and is specifically correlated with enhanced pulmonary damage, edema accumulation and death.  Calcium ions together with pH modulated E protein pore charge and selectivity (Nieto-Torres et al. 2015). There is a single transmembrane domain in E, suggesting an allosteric interaction between extramembrane and transmembrane domains (To et al. 2016).

Viruses
Nidovirales
Protein E of SARS (NP_828854) (Q19QW7)
*1.A.65.1.3









Envelope small membrane viroporin protein of 82 aas and 1 TMS, protein E or sM.  Viroporin inhibitors have been identified (Takano et al. 2015).

Viruses
Nidovirales
Viroporin of feline infectious peritonitis virus (FIPV)
*1.A.65.1.4









MERS CoV Viroporin of 82 aas and 1 TMS.  Induces the formation of pentameric hydrophilic pores in cellular membranes followed by apoptosis (Surya et al. 2015).

Viruses
Nidovirales
Viroporin of Human Middle East respiratory syndrome coronavirus (MERS CoV) or EMC (HCoV-EMC)
*1.A.65.1.5









ORF5-E fusion protein of 194 aa

Viruses
Nidovirales
Orf5-E of Middle East respiratory syndrome-related coronavirus
*1.A.65.1.6









Envelope protein of 75 aas and 1 TMS.

Viruses
Nidovirales
Envelope small protein of Alphacoronavirus Bat-CoV/P. kuhlii
*1.A.65.1.7









Envelope (E) viroporin protein, ORF5, of 75 aas and 1 N-terminal TMS

Viruses
Nidovirales
E-protein of severe acute respiratory syndrome coronavirus 2
*1.A.65.1.8









Protein-E of 78 aas and 2 TMSs.

Viruses
Nidovirales
E-protein of rodent coronavirus
*1.A.65.1.9









E-protein of 89 aas and 2 TMSs

Viruses
Nidovirales
E-protein of rabbit coronavirus