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1.A.69.3.3
Gustatory receptor 28b isoform D of 470 aas and 8 TMSs. It mediates acceptance or avoidance behavior, depending on its substrates. Its atypical expression suggests additional nongustatory roles in the nervous system and tissues involved in proprioception (warmth receptor), hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands (Thorne and Amrein 2008). Saponins function in natural self-defense for plants to deter various insects due to their unpleasant taste and toxicity. Sang et al. 2019 provided evidence that saponin from Quillaja saponaria functions as an antifeedant as well as an insecticide to ward off insects in both the larval and the adult stages.

Accession Number:Q9VM08
Protein Name:Putative gustatory receptor 28b
Length:470
Molecular Weight:53598.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: NOG44416
Entrez Gene ID: 117496   
Pfam: PF08395   
KEGG: dme:Dmel_CG1378   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008527 F:taste receptor activity
GO:0007631 P:feeding behavior
GO:0035006 P:melanization defense response

References (3)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system.”  Dunipace L.et.al.   11516643

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDIEMAKEPV NPTDTPDIEV TPGLCQPLRR RFRRFVTAKQ LYECLRPVFH VTYIHGLTSF 
61:	YISCDTKTGK KAIKKTIFGY INGIMHIAMF VFAYSLTIYN NCESVASYFF RSRITYFGDL 
121:	MQIVSGFIGV TVIYLTAFVP NHRLERCLQK FHTMDVQLQT VGVKIMYSKV LRFSYMVLIS 
181:	MFLVNVLFTG GTFSVLYSSE VAPTMALHFT FLIQHTVIAI AIALFSCFTY LVEMRLVMVN 
241:	KVLKNLAHQW DTRSLKAVNQ KQRSLQCLDS FSMYTIVTKD PAEIIQESME IHHLICEAAA 
301:	TANKYFTYQL LTIISIAFLI IVFDAYYVLE TLLGKSKRES KFKTVEFVTF FSCQMILYLI 
361:	AIISIVEGSN RAIKKSEKTG GIVHSLLNKT KSAEVKEKLQ QFSMQLMHLK INFTAAGLFN 
421:	IDRTLYFTIS GALTTYLIIL LQFTSNSPNN GYGNGSSCCE TFNNMTNHTL