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1.A.7.1.8
The p2X purinoreceptor 4a of 389 aas and 2 TMSs, P2X4a of 388 aas and 2 TMSs. A splice variant of 361 aas also exists and may form heterotrimers with P2RX4a (Townsend-Nicholson et al. 1999). Plays a role in alcoholism (Franklin et al. 2014). P2RX4 deficiency alleviates allergen-induced airway inflamation (Zech et al. 2016).

Accession Number:Q6NYR1
Protein Name:p2X purinoceptor
Length:389
Molecular Weight:43971.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

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  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSESVGCCDS VSQCFFDYYT SKILIIRSKK VGTLNRFTQA LVIAYVIGYV CVYNKGYQDT 
61:	DTVLSSVTTK VKGIALTNTS ELGERIWDVA DYIIPPQEDG SFFVLTNMII TTNQTQSKCA 
121:	ENPTPASTCT SHRDCKRGFN DARGDGVRTG RCVSYSASVK TCEVLSWCPL EKIVDPPNPP 
181:	LLADAENFTV LIKNNIRYPK FNFNKRNILP NINSSYLTHC VFSRKTDPDC PIFRLGDIVG 
241:	EAEEDFQIMA VHGGVMGVQI RWDCDLDMPQ SWCVPRYTFR RLDNKDPDNN VAPGYNFRFA 
301:	KYYKNSDGTE TRTLIKGYGI RFDVMVFGQA GKFNIIPTLL NIGAGLALLG LVNVICDWIV 
361:	LTFMKRKQHY KEQKYTYVDD FGLLHNEDK