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1.A.7.1.9
Purinorepector, P2X7 (P2RX7) of 595 aas and 2 TMSs.  The crystal structure in complex with a series of allosteric antagonists were published, giving insight into the mechanism of channel antagonism (Pasqualetto et al. 2018).

Accession Number:G1M6C4
Protein Name:p2X purinoceptor
Length:595
Molecular Weight:68341.00
Species:Ailuropoda melanoleuca (Giant panda) [9646]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	TMPACCSWKD VFQYETNKVL RIQSTNYGTI KWIFHVLVFS YISFALISDK RYQKKEPLIS 
61:	SVHTKVKGIA EVKAEILENG MKKMVSGVFD TADYTFPLQG NSFFVMTNFI KTEGQQQGLC 
121:	PDFPTRRTIC SSDRGCKKGR MDPQSKGIQT GRCVVYKERL KTCEVSAWCP IEEVEDAPRP 
181:	ALLNSAENFT VLIKNNIDFP GHNYTTRNIL PGVNITCTFH KTQNPQCPIF RLGDIFQETG 
241:	DNFSDVAIQG GIMGIEIYWD CNLDGWFHHC RPKYSFRRLD DKTTNESLYP GYNFRYAKYY 
301:	KENNVEKRTL IKVFGIRFDI LVFGTGGKFN VIQLAVYIGS VISYFGLATV FIDILINTYS 
361:	SKCCRSRIYP CFKCCEYCAV NEYYYRKQSE PIAEPKPTLK YVSFVDETHI RMVDQQLLGK 
421:	SLQNVKGEKV QRPSVDFTDL SRLSLSLCDP TPIPGQPEEM QLFSEEVTPR SSNSPDWCQC 
481:	GHCLPSQLPE SHRCLEELCC RKKAGACITT SEPFRKLVLS RQVLQFLLLY QEPLLVLDGN 
541:	SSSRLRHCAY RCYTTWRFGS PDLADFAILP SCCRWRIRRE FPKSEGQYTG FQSPY