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1.A.77.1.15
MCU of 488 aas and 2 TMSs.  The 3.8 Å cryoEM structure has been solved (Nguyen et al. 2018). The channel is a homotetramer with two-fold symmetry in its amino-terminal domain (NTD) that adopts a structure similar to that of human MCU. The NTD assembles as a dimer of dimers to form a tetrameric ring that connects to the transmembrane domain through an elongated coiled-coil domain. The ion-conducting pore domain maintains four-fold symmetry, with the selectivity filter positioned at the start of the pore-forming TM2 helix. The aspartate and glutamate sidechains of the conserved DIME motif are oriented towards the central axis and separated by one helical turn (Nguyen et al. 2018).

Accession Number:A1CWT6
Protein Name:Uncharacterized protein
Length:488
Molecular Weight:55745.00
Species:Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) [331117]
Number of TMSs:2
Substrate

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FASTA formatted sequence
1:	MRALVSRTPI AAALRSATLG SQCASIQYNS LNILDRLPQP LPSRSFRIRY TGVSTSGRVT 
61:	QTCRRSFQLS ASSRDKRGPQ SAEPDPLERL EVKKVQQQHE NEKDDSGRDT KSGGKVAKAM 
121:	TKGDTIAGKL LTTPSRLFKL LIPLTTINRK DIEQIAILIH PQQPLSHLER LIQSEVPPIE 
181:	DENGQKRPPA VSFIALQLEQ DAIRPKRGMY EGTDAEIHRV EGGKDDATVA KRGEDFQEVD 
241:	ETFSYLRRPG PGQGDKEQRF IRWSQSTEIG DFIRDAARAK EFIVTIEGAP AGLEQIHVAV 
301:	PSFDERTYFL RMRLRKISRR IQGLAEIKHE CDALAHRGAQ RVALGGFGIL AFWWYIVYKL 
361:	TFETDLGWDT MEPVTYLVSL STLMGGYLWF LYHNREISYR SALDFTINAR QKKLYQMKGI 
421:	DLQVWESLID EANAIRREIK NIAAEYDVDW DERKDEQDDR VTEALKKERR LKNGSQKEER 
481:	PKDDRDDD