TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.77.1.1









Inner membrane 40KD Mitochondrial Ca2+ Channel-forming Uniporter, MCU (DUF607; 350 aas; coiled coil domain protein 109 A) (De Stefani et al., 2011; Drago et al., 2011).  It functions with MICU1, and essential component of the system, and the gatekeeper for Ca2+ uptake (Mallilankaraman et al. 2012a; Mallilankaraman et al. 2012b).  Contributes to metabolism-insulin secretion coupling in clonal pancreatic beta-cells (Alam et al. 2012).  MCU-mediated Ca2+ uptake in beta cells is essential to establish a nutrient-induced mitochondrial pH gradient which is critical for sustained ATP synthesis and metabolism-secretion coupling in insulin-releasing cells (Quan et al. 2015).

Eukaryota
Metazoa
MCU of Mus musculus (Q3UMR5)
*1.A.77.1.2









MCU homologue of 338 aas; 2 TMSs

Eukaryota
Viridiplantae
MCU homologue of Arabidopsis thaliana (Q1PE15)
*1.A.77.1.3









Algal MCU homologue (300 aas; 2 TMSs)

Eukaryota
Viridiplantae
MCU homologue of Chlamydomonas reinhardtii (A8J6W0)
*1.A.77.1.4









Slime mold MCU homologue (275 aas; 2 TMSs)

Eukaryota
Dictyosteliida
MCU homologue of Dictyostellium discoideum (Q54LT0)
*1.A.77.1.5









Fungal MCU homologue of 493 aas and 2 TMS. The cryo-electron microscopy structure of the full-length MCU to an overall resolution of ~3.7 Å has been determined (Yoo et al. 2018). The structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of the MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore (Yoo et al. 2018).

Eukaryota
Fungi
MCU homologue of Neurospora crassa (Q7S4I4)
*1.A.77.1.6









MCU homologue of 355 aas; 4 TMSs (2+2) (Docampo et al. 2013).

Eukaryota
Kinetoplastida
MCU homologue of Trypanosoma cruzi (E7KWU4)
*1.A.77.1.7









Mitochondrial Ca2+ Uniporter, a channel complex. MCU is a putative 5TMS protein (307 aas) with homology to MCU Ca2+/Mg2+ channels in the C-terminal 2TMS domain. The N-terminal domain is found only in Trypanosoma and Leishmania species. The TbMCU complex possesses four subunits, MCU (307 aas), MCUb (214 aas), MCUc (254 aas) and MCUd (249 aas)), present only in trypanosomatids and required for Ca2+ transport. These four subunits  interact through their transmembrane helices to form hetero-oligomers in a ~380 KDa complex (Huang and Docampo 2018).

Eukaryota
Kinetoplastida
Channel homologues of Trypanosoma brucei
MCU
MCUb
MCUc
MCUd
*1.A.77.1.8









Ciliate MCU homologue 362 aas; 2 TMSs

Eukaryota
Intramacronucleata
MCU homologue of Paramecium tetraurelia (A0E7U6)
*1.A.77.1.9









MCU homologue (766 aas; 2 TMSs)

Bacteria
Bacteroidetes/Chlorobi group
MCU homologue of Cytophaga hutchinsonii (Q11Z39)
*1.A.77.1.10









MCU homologue (355 aas; 2 TMSs)

Bacteria
Bacteroidetes/Chlorobi group
MCU homologue of Chlorobium phaeobacteroides (A1BIL6)
*1.A.77.1.11









Mitochondrial calcium uniporter, MCU, of 362 aas

Eukaryota
Intramacronucleata
MCU of Tetrahymena thermophila
*1.A.77.1.12









The mitochondrial calcium uniporter regulatory subunit MCUb of 336 aas; part of the MCU complex (Sancak et al. 2013). MCU regulates procoagulant platelet formation (Kholmukhamedov et al. 2018).

Eukaryota
Metazoa
MCUb of Homo sapiens
*1.A.77.1.13









Mitochondrial calcium uniporter of 658 aas (Docampo et al. 2013).

Eukaryota
Choanoflagellida
MCU of Monosiga brevicollis
*1.A.77.1.14









Mitochondrial calcium uniporter of 297 aas.

Eukaryota
Kinetoplastida
MCU of Leishmania donovani
*1.A.77.1.15









MCU of 488 aas and 2 TMSs.  The 3.8 Å cryoEM structure has been solved (Nguyen et al. 2018). The channel is a homotetramer with two-fold symmetry in its amino-terminal domain (NTD) that adopts a structure similar to that of human MCU. The NTD assembles as a dimer of dimers to form a tetrameric ring that connects to the transmembrane domain through an elongated coiled-coil domain. The ion-conducting pore domain maintains four-fold symmetry, with the selectivity filter positioned at the start of the pore-forming TM2 helix. The aspartate and glutamate sidechains of the conserved DIME motif are oriented towards the central axis and separated by one helical turn (Nguyen et al. 2018).

Eukaryota
Fungi
MCU of the fungus, Neosartorya fischeri
*1.A.77.2.1









Putative Mg2+ transporter, AtpZ

Bacteria
Proteobacteria
AtpZ of Helicobacter pylori (Q1CUJ6)
*1.A.77.2.2









AtpZ homologue (125 aas; 2 TMSs)

Bacteria
Proteobacteria
AtpZ homologue of Anaeromyxobacter sp. Fw109-5 (A7HIX1)
*1.A.77.2.3









AtpZ of 92 aas

Bacteria
Proteobacteria
AtpZ of Desulfovibrio vulgaris (A1VF64)
*1.A.77.2.4









AtpZ of 106 aas

Bacteria
Bacteroidetes/Chlorobi group
AtpZ of Chlorobium tepidum (Q8KGE5)
*1.A.77.2.5









AtpZ of 105 aas

AtpZ of Rhodomicrobium vannielii (E3I7U2)
*1.A.77.2.6









AtpZ of 108 aas

Bacteria
Proteobacteria
AtpZ of Maricaulis maris (Q0AMJ5)
*1.A.77.2.7









ATP synthase protein Z of 114 aas

Bacteria
Proteobacteria
AtpZ of Rhodobacter capsulatus
*1.A.77.2.8









The Mg2+ uptake channel, AtpZ.  Postulated to form homo- and/or hetero oligomers [(AtpZ)n-x (AtpI)x] (Hicks et al., 2003).  The AtpI homologue (P22475) is in subfamily 1.A.77.3 and has TC# 1.A.77.3.1.

Bacteria
Firmicutes
The AtpZI Mg2+/Ca2+ channel of Bacillus pseudofirmus
AtpZ (Q9EXJ9)
*1.A.77.2.9









AtpZ of 112 aas.

 

Archaea
Euryarchaeota
AtpI of Methanosarcina acetivorans (Q8TN54)
*1.A.77.2.10









AtpZ homologue of 87 aas.

Bacteria
Proteobacteria
AtpZ of Hippea maritima
*1.A.77.2.11









AtpZ homologue of 90 aas

Bacteria
Proteobacteria
AtpZ of Campylobacter curvus
*1.A.77.2.12









AtpZ homologue of 60 aas

Archaea
Euryarchaeota
AtpZ homologue of Methanothermococcus okinawensis
*1.A.77.2.13









AtpZ homologue of 80 aas

Bacteria
Proteobacteria
AtpZ of Geobacter metallireducens
*1.A.77.2.14









AtpZ homologue of 105 aas

Bacteria
Proteobacteria
AtpZ of Acidophilium multivorum
*1.A.77.2.15









AtpZ homologue of 96 aas

Bacteria
Proteobacteria
AtpZ of Tistrella mobilis
*1.A.77.2.16









Putative Mg2+ channel of 113 aas and 2 TMSs. Part of the F-type ATPase (Morales-Rios et al. 2015).

Bacteria
Proteobacteria
Magnesium channel of Paracoccus denitrificans
*1.A.77.2.17









Putative Mg2+ channel, AtpI, that functions with a Na+-transporting F-type ATPase (Soontharapirakkul et al. 2011).

Bacteria
Cyanobacteria
AtpI of Aphanothece halophytica
*1.A.77.3.1









AtpI of 133 aas,  This protein is a part of a two component channel and as such is also listed with TC# 1.A.77.2.8.

Bacteria
Firmicutes
AtpI of Bacillus pseudofirmus
*1.A.77.3.2









ATP synthase protein I
Bacteria
Firmicutes
AtpI of Bacillus subtilis
*1.A.77.3.3









ATP synthase subunit I

Bacteria
Proteobacteria
AtpI of Desulfococcus oleovorans
*1.A.77.3.4









ATP synthase protein I
Bacteria
Firmicutes
AtpI of Bacillus megaterium
*1.A.77.3.5









AtpI homologue

Bacteria
Firmicutes
AtpI homologue of Coprococcus catus
*1.A.77.3.6









AtpI homologue of 122aas and 4 TMSs

Bacteria
Firmicutes
AtpI homologue of Paenibacillus mucilaginosus
*1.A.77.3.7









ATP synthase protein I
Bacteria
Proteobacteria
AtpI of Vibrio cholerae serotype O1
*1.A.77.3.8









AtpI homologue of 150 aas

Bacteria
Proteobacteria
AtpI of Klebsiella pneumoniae
*1.A.77.3.9









AtpI homologue of 135 aas

Bacteria
Proteobacteria
AtpI of Pseudomonas putida
*1.A.77.3.10









AtpI homologue of 126 aas

Bacteria
Proteobacteria
AtpI of Ferrimonas balearica
*1.A.77.3.11









AtpI of 126 aas

Bacteria
Proteobacteria
AtpI of E. coli
*1.A.77.3.12









AtpI homologue of 185 aas

Bacteria
Proteobacteria
AtpI of Ralstonia solanacearum
*1.A.77.3.13









ATP synthase protein I
Bacteria
Tenericutes
AtpI of Mycoplasma gallisepticum )
*1.A.77.3.14









ATP synthase I, AtpI

Bacteria
Firmicutes
AtpI of Acetohalobium arabaticum
*1.A.77.3.15









ATP synthase subunit I

Bacteria
Proteobacteria
AtpI of Geobacter uraniireducens
*1.A.77.3.16









ATP synthase I

Bacteria
Thermotogae
AtpI of Fervidobacterium pennivorans
*1.A.77.3.17









AtpI of the Na+ ATPase.  Essential for assembly of the c-ring of the rotor (Brandt et al. 2013).

Bacteria
Firmicutes
AtpI of Acetobacterium woodii
*1.A.77.3.18









AtpI homologue of 122 aas and 4 TMSs

Bacteria
Firmicutes
AtpI homologue of Clostridium sticklandii
*1.A.77.3.19









AtpI homologue of 109 aas

Bacteria
Thermotogae
AtpI of Thermatoga thermarum
*1.A.77.3.20









ATP synthase, subunit I of 117 aas and 4 TMSs

Bacteria
Firmicutes
AtpI of Staphylococcus aureus
*1.A.77.3.21









Bacteria
Cyanobacteria
AtpI of Synechococcus sp.
*1.A.77.3.22









ATP snthase subunit I, AtpI of 147 aas

Bacteria
Firmicutes
AtpI of Halothermothrix orenii
*1.A.77.3.23









ATP synthase, subunit I, AtpI of 153 aas

Bacteria
Actinobacteria
AtpI of Mycobacterium leprae
*1.A.77.3.24









AtpI of 255 aas and 4 TM

Eukaryota
Bangiophyceae
AtpI of Galdieria sulfuraria
*1.A.77.3.25









Putative AtpI of 122 aas and 4 TMSs

Bacteria
Deferribacteres
AtpI of Denitrovibrio acetophilus
*1.A.77.3.26









Uncharacterized protein of 189 aas and 5 TMSs

Bacteria
Proteobacteria
UP of Anaeromyxobacter dehalogenans
*1.A.77.3.27









AtpI homologue of 133 aas

Bacteria
Fusobacteria
AtpI of Leptotrichia buccalis
*1.A.77.3.28









AtpI homologue of 126 aas

Bacteria
Fusobacteria
AtpI of Ilyobacter polytrophus
*1.A.77.3.29









AtpI homologue of 127 aas

Bacteria
Fusobacteria
AtpI of Propionigenium modestum
*1.A.77.3.30









AtpI homologue of 135 aas

Bacteria
Fusobacteria
AtpI of Sebaldella termitidis
*1.A.77.3.31









AtpI homologue of 164aas and 4 TMSs

Bacteria
Tenericutes
AtpI of Mycoplasma fermentans
*1.A.77.3.32









AtpI homologue of 150 aas

Bacteria
Tenericutes
AtpI of Mycoplasma arthritidis
*1.A.77.3.33









AtpI homologue of 161 aas

Bacteria
Tenericutes
AtpI of Mycoplasma synoviae
*1.A.77.3.34









AtpI of 140 aas and 4 TMSs

Bacteria
Proteobacteria
AtpI of Desulfotalea psychrophila
*1.A.77.3.35









Putative AtpI of 129 aas and 4 TMSs

Bacteria
Firmicutes
AtpI of Heliobacterium modesticaldum
*1.A.77.3.36









Putative AtpI of 139 aas and 4 TMSs

Bacteria
Fibrobacteres/Acidobacteria group
AtpI of Candidatus Koribacter versatilis
*1.A.77.3.37









Putative AtpI of 133 aas and 4 TMSs

Bacteria
Proteobacteria
AtpI of Desulfobacula toluolica
*1.A.77.3.38









Putative AtpI of 140 aas and 4 TMSs

Bacteria
Proteobacteria
AtpI of Syntrophus aciditrophicus
*1.A.77.3.39









Putative AtpI of 256 aas and 4 or 5 TMSs.  The N-terminus may include a single TMS plus a hydrophilic domain before the C-terminal AtpI domain.

Eukaryota
Florideophyceae
AtpI of Chondrus crispus
*1.A.77.3.40









AtpI of 156 aas and 4 TMSs

Eukaryota
Euglyphida
AtpI of Paulinella chromatophora
*1.A.77.3.41









Putative AtpI of 119 aas and 4 TMSs

Bacteria
Deferribacteres
AtpI of Deferribacter desulfuricans
*1.A.77.3.42









Putative AtpI of 138 aas and 4 TMSs

Bacteria
Fibrobacteres/Acidobacteria group
AtpI of Granulicella tundricola
*1.A.77.3.43









Putative AtpI of 121 aas and 4 TMSs

Bacteria
Nitrospirae
AtpI of Thermodesulfovibrio yellowstonii
*1.A.77.3.44









Putative AtpI of 160 aas and 4 TMSs

Bacteria
Tenericutes
AtpI of Mycoplasma mobile
*1.A.77.3.45









ATP synthase I-like protein, AtpI, of 385 aas amd 3 - 4 TMSs.

Eukaryota
Viridiplantae
AtpI of Chlamydomonas reinhardtii (Chlamydomonas smithii)
*1.A.77.4.1









Fusion protein with N-terminal 4 TMS AtpI domain and large soluble C-terminal α/β-hydrolase domain.

Eukaryota
Bangiophyceae
Fusion protein of Galdieria sulphuraria
*1.A.77.4.2









Fusion protein with N-terminal 4 TMS AtpI domain and large soluble C-terminal α/β-hydrolase domain.

Eukaryota
Dictyosteliida
Fusion protein of Dictyostelium discoideum
*1.A.77.4.3









Fusion protein with N-terminal 4 TMS AtpI domain and large soluble C-terminal α/β-hydrolase domain.

Eukaryota
Entamoeba
Fusion protein of Entamoeba histolytica
*1.A.77.5.1









AtpI homologue of 147 aas

Bacteria
Actinobacteria
AtpI of Corynebacterium diphtheriae
*1.A.77.5.2









AtpI homologue of 137 aas

Bacteria
Actinobacteria
AtpI of Streptomyces avermitilis
*1.A.77.5.3









AtpI homologue of 145 aas

Bacteria
Actinobacteria
AtpI of Frankia alni
*1.A.77.5.4









Putative AtpI of 177 aas and 4 TMSs

Bacteria
Actinobacteria
AtpI of Saccharomonospora cyanea
*1.A.77.5.5









Putative ATP synthase protein I2 of 161 aas and 4 TMSs

Bacteria
Actinobacteria
Putative reductase of Actinokineospora spheciospongiae
*1.A.77.5.6









Uncharacterized protein of 157 aas and 3-4 TMSs

Bacteria
Actinobacteria
UP of Cellulomonas fimi