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1.A.8.10.9
Aquaporin TIP1-2 (Gamma-tonoplast intrinsic protein 2) (Gamma-TIP2) (Salt stress-induced tonoplast intrinsic protein) (Tonoplast intrinsic protein 1-2) (AtTIP1;2)

Accession Number:Q41963
Protein Name:Aquaporin TIP1-2
Length:253
Molecular Weight:25849.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Genevestigator: Q41963
eggNOG: COG0580
HEGENOM: HOG000288286
Entrez Gene ID: 822259   
Pfam: PF00230   
KEGG: ath:AT3G26520   

Gene Ontology

GO:0009507 C:chloroplast
GO:0043674 C:columella
GO:0005783 C:endoplasmic reticulum
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005774 C:vacuolar membrane
GO:0005215 F:transporter activity
GO:0042742 P:defense response to bacterium
GO:0080170 P:hydrogen peroxide transmembrane transport
GO:0030104 P:water homeostasis

References (8)

[1] “Characterization of two new channel protein genes in Arabidopsis.”  Pih K.T.et.al.   10102577
[2] “Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10819329
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “An inventory of 1152 expressed sequence tags obtained by partial sequencing of cDNAs from Arabidopsis thaliana.”  Hoefte H.et.al.   8281187
[5] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824
[6] “Urea transport by nitrogen-regulated tonoplast intrinsic proteins in Arabidopsis.”  Liu L.-H.et.al.   14576283
[7] “Arabidopsis tonoplast proteins TIP1 and TIP2 interact with the cucumber mosaic virus 1a replication protein.”  Kim M.J.et.al.   17030879
[8] “Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes.”  Bienert G.P.et.al.   17105724

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPTRNIAIGG VQEEVYHPNA LRAALAEFIS TLIFVFAGSG SGIAFNKITD NGATTPSGLV 
61:	AAALAHAFGL FVAVSVGANI SGGHVNPAVT FGVLLGGNIT LLRGILYWIA QLLGSVAACF 
121:	LLSFATGGEP IPAFGLSAGV GSLNALVFEI VMTFGLVYTV YATAVDPKNG SLGTIAPIAI 
181:	GFIVGANILA GGAFSGASMN PAVAFGPAVV SWTWTNHWVY WAGPLIGGGL AGIIYDFVFI 
241:	DENAHEQLPT TDY