TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.8.12.4
The root-expressed MIP transporter of lactic acid, NIP2;1 (Nod26-like MIP-4; NLM4) (induced by water logging and anoxic stress; shows minimal water and glycerol transport). It may play a role in adaptation to lactic fermentaion under anaerobic stress (Choi and Roberts, 2007). Lactic acid transport is induced by anoxic stress (Choi and Roberts, 2007).

Accession Number:Q8W037
Protein Name:Aquaporin NIP2-1
Length:288
Molecular Weight:30581.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Lactic acid, water, glycerol

Cross database links:

Genevestigator: Q8W037
HEGENOM: HBG705794
RefSeq: NP_180986.1   
Entrez Gene ID: 818002   
Pfam: PF00230   
KEGG: ath:AT2G34390   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015129 F:lactate transmembrane transporter activity
GO:0015727 P:lactate transport
GO:0001666 P:response to hypoxia
GO:0055085 P:transmembrane transport

References (3)

[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[2] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824
[3] “Aquaporin NIP2;1 is mainly localized to the ER membrane and shows root-specific accumulation in Arabidopsis thaliana.”  Mizutani M.et.al.   16954136

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDDISVSKSN HGNVVVLNIK ASSLADTSLP SNKHESSSPP LLSVHFLQKL LAELVGTYYL 
61:	IFAGCAAIAV NAQHNHVVTL VGIAVVWGIV IMVLVYCLGH LSAHFNPAVT LALASSQRFP 
121:	LNQVPAYITV QVIGSTLASA TLRLLFDLNN DVCSKKHDVF LGSSPSGSDL QAFVMEFIIT 
181:	GFLMLVVCAV TTTKRTTEEL EGLIIGATVT LNVIFAGEVS GASMNPARSI GPALVWGCYK 
241:	GIWIYLLAPT LGAVSGALIH KMLPSIQNAE PEFSKTGSSH KRVTDLPL