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1.A.8.13.2
Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al., 2003; Araya-Secchi et al., 2011). 

Accession Number:Q9C4Z5
Protein Name:AqpM
Length:246
Molecular Weight:25348.00
Species:Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133) [79929]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate water, glycerol, CO2

Cross database links:

Pfam: PF00230   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (2)

[1] “Rapid amplification of a water channel-like gene and its flanking sequences from the Methanothermobacter marburgensis genome using a single primer PCR strategy.”  Ding X.et.al.   16233136
[2] “Functional expression and characterization of an archaeal aquaporin. AqpM from Methanothermobacter marburgensis.”  Kozono D.et.al.   12519768
Structure:
2EVU   2F2B     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVSLTKRCIA EFIGTFILVF FGAGSAAVTL MIASGGTSPN PFNIGIGLLG GLGDWVAIGL 
61:	AFGFAIAASI YALGNISGCH INPAVTIGLW SVKKFPGREV VPYIIAQLLG AAFGSFIFLQ 
121:	CAGIGAATVG GLGATAPFPG ISYWQAMLAE VVGTFLLMIT IMGIAVDERA PKGFAGIIIG 
181:	LTVAGIITTL GNISGSSLNP ARTFGPYLND MIFAGTDLWN YYSIYVIGPI VGAVLAALTY 
241:	QYLTSE