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1.A.8.4.2
Aquaporin-12A (AQP-12) of 295 aas and probably 7 TMSs with an extra N-terminal TMS. Bears a C-terminal KKXX-like ER retention sequence and is found intracelllularly (Ishibashi 2006).  It is expressed in elevated amounts in exocrine glandular cells of the pancreas (Danielsson et al. 2014).

Accession Number:Q8IXF9
Protein Name:Aquaporin-12A
Length:295
Molecular Weight:31475.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Genevestigator: Q8IXF9
eggNOG: NOG46671
HEGENOM: HOG000034023
Entrez Gene ID: 375318   
Pfam: PF00230   
KEGG: hsa:375318   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity

References (1)

[1] “Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.”  Itoh T.et.al.   15809071

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL 
61:	LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL LKLAAQGLGM QAACTLMRLC 
121:	WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV 
181:	ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG 
241:	RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS