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1.A.8.6.2
Aquaporin-2 Aqy2 (plays a role in reducing surface hydrophobicity promoting cell dispersion during starvation and reproduction)

Accession Number:P0CD89
Protein Name:Aquaporin-2
Length:289
Molecular Weight:31284.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Pfam: PF00230   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (6)

[1] “Polymorphism of Saccharomyces cerevisiae aquaporins.”  Laize V.et.al.   10870101
[2] “Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains.”  Bonhivers M.et.al.   9765289
[3] “Aquaporins in Saccharomyces: characterization of a second functional water channel protein.”  Carbrey J.M.et.al.   11158584
[4] “Existence of a tightly regulated water channel in Saccharomyces cerevisiae.”  Meyrial V.et.al.   11168368
[5] “Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains.”  Tanghe A.et.al.   12450819
[6] “Aquaporin-mediated improvement of freeze tolerance of Saccharomyces cerevisiae is restricted to rapid freezing conditions.”  Tanghe A.et.al.   15184134

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNESNDLEK NISHLDPTGV DNAYIPPEQP ETKHSRFNID RDTLRNHFIA AVGEFCGTFM 
61:	FLWCAYVICN VANHDVALTT EPEGSHPGQL IMIALGFGFS VMFSIWCFAG VSGGALNPAV 
121:	SLSLCLARAI SPARCVVMWF PQIIAGMAAG GAASAMTPGK VLFTNALGLG CSRSRGLFLE 
181:	MFGTAVLCLT VLMTAVEKRE TNFMAALPIG ISLFMAHMAL TGYTGTGVNP ARSLGAAVAA 
241:	RYFPHYHWIY WIGPLLGAFL AWSVWQLLQI LDYTTYVNAE KAAGQKKED