TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.8.6.3
Aquaporin, Aqy1 (PIP2-7 7).  The subangstron (0.88Å) structure is available (Kosinska Eriksson et al. 2013).  the H-bond donor interactions of the NPA motif''s asparagine residues to passing water molecules are revealed. A polarized water-water H-bond configuration is observed within the channel.  Four selectivity filter water positions are too closely spaced to be simultaneously occupied. Strongly correlated movements break the connectivity of selectivity filter water molecules to other water molecules within the channel, thereby preventing proton transport via a Grotthuss mechanism.

Accession Number:F2QVG4
Protein Name:Aquaporin PIP2-7 7
Length:279
Molecular Weight:29915.00
Species:Komagataella pastoris (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1) (Yeast) [981350]
Number of TMSs:6
Substrate water

Cross database links:

Structure:
2W1P   2W2E   3ZOJ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPDIENQAAD GQAEIKPEDA PYITNAYKPA YARWGFGSDS VRNHFIAMSG EFVGTFLFLW 
61:	SAFVIAQIAN QAPETPDGGS NPAQLIMISF GFGFGVMVGV FITYRVSGGN LNPAVTLALV 
121:	LARAIPPFRG ILMAFTQIVA GMAAAGAASA MTPGEIAFAN ALGGGASRTR GLFLEAFGTA 
181:	ILCLTVLMLA VEKHRATWFA PFVIGIALLI AHLICIYYTG AGLNPARSFG PAVAARSFPN 
241:	YHWIYWLGPI LGAFLAYSIW QMWKWLNYQT TNPGQDSDA