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1.A.8.8.3
The BIB aquaporin of D. melanogaster (transports ions by a channel mechanism involving E71 in TMS1) (Yool, 2007).

Accession Number:P23645
Protein Name:BIB
Length:696
Molecular Weight:76509.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

eggNOG: inNOG09276
DIP: DIP-21188N
RefSeq: NP_476837.1   
Entrez Gene ID: 34330   
Pfam: PF00230   
KEGG: dme:Dmel_CG4722   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005261 F:cation channel activity
GO:0016337 P:cell-cell adhesion
GO:0007398 P:ectoderm development
GO:0006811 P:ion transport
GO:0007498 P:mesoderm development
GO:0007399 P:nervous system development
GO:0007219 P:Notch signaling pathway
GO:0030707 P:ovarian follicle cell development
GO:0055085 P:transmembrane transport

References (9)

[1] “Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.”  Rao Y.et.al.   1692392
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[5] “The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.”  Rao Y.et.al.   1483394
[6] “The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.”  Doherty D.et.al.   9367444
[7] “Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain.”  Yanochko G.M.et.al.   11923418
[8] “Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes.”  Yanochko G.M.et.al.   14990474
[9] “Phosphoproteome analysis of Drosophila melanogaster embryos.”  Zhai B.et.al.   18327897

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADESLHTVP LEHNIDYHIV TLFERLEAMR KDSHGGGHGV NNRLSSTLQA PKRSMQAEIR 
61:	TLEFWRSIIS ECLASFMYVF IVCGAAAGVG VGASVSSVLL ATALASGLAM ATLTQCFLHI 
121:	SGAHINPAVT LALCVVRSIS PIRAAMYITA QCGGGIAGAA LLYGVTVPGY QGNLQAAISH 
181:	SAALAAWERF GVEFILTFLV VLCYFVSTDP MKKFMGNSAA SIGCAYSACC FVSMPYLNPA 
241:	RSLGPSFVLN KWDSHWVYWF GPLVGGMASG LVYEYIFNSR NRNLRHNKGS IDNDSSSIHS 
301:	EDELNYDMDM EKPNKYQQSQ GTYPRGQSNG NGGGQAAGNG QHQAANMGQM PGVVANAGQG 
361:	NYCQNLYTAP PLSSKYDQQQ EPLYGGTRSL YCRSPTLTRS NLNRSQSVYA KSNTAINRDI 
421:	VPRPGPLVPA QSLYPMRTQQ QQQQQQQQQQ QVAPAPQSSH LQNQNVQNQM QQRSESIYGM 
481:	RGSMRGQQQP IQQQQQQQQQ QQLQQQQPNM GVQQQQMQPP PQMMSDPQQQ PQGFQPVYGT 
541:	RTNPTPMDGN HKYDRRDPQQ MYGVTGPRNR GQSAQSDDSS YGSYHGSAVT PPARHPSVEP 
601:	SPPPPPMLMY APPPQPNAAH PQPIRTQSER KVSAPVVVSQ PAACAVTYTT SQGSAVTAQQ 
661:	QQQQQQQQQQ QQQQQQQQMM MQQQQQHYGM LPLRPN