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1.A.8.9.3
Major aquaglyceroporin, LmAQP1: transports water, glycerol, methylglyoxal, trivalent metalloids such as arsenite and antimonite, dihydroxyacetone and sugar alcohols. Also takes up the activated form or the drug, pentostam.  It localizes to the flagellum of the Leishmania promastigotes and is used to regulate volume in response to hypoosmotic stress, functions in osmotaxis) (Figarella et al., 2005; Gourbal et al, 2004).

Accession Number:Q6Q1Q6
Protein Name:Aquaglyceropoin
Length:281
Molecular Weight:31438.00
Species:Leishmania major [5664]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Peripheral membrane protein2
Substrate water, glycerol, Methylglyoxal, Me3+, Dihydroxyacetone, Sugar alcohols, Pentostam

Cross database links:

Pfam: PF00230   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (1)

[1] “Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.”  Gourbal B.et.al.   15138256

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHEEEEDQHE SKRNFMSQNR WPLYRYRWRL REYVAEFFGT FFLVTFGTGV VATTVFHGGT 
61:	TAMYQSNSSY LAITFGWAFG LAISLFLSMA VSGGHLNPAV TLANCVFGTF PWVKLPGYFL 
121:	AQFLGGFVGA ANTYVLFKSH FDEAEKRLLL NETMASKYGG IFATYPNVAN TYAVWSEVFN 
181:	TMALMMGILA ITDARMTPAV DYKPVAIGLL LFVIGIASGI NSSYGLNPAR DLSPRILSAM 
241:	LWGSEPFTLH SYYFWIPLVV PFVGALFGMF LYVFFIIPPS C