TCDB is operated by the Saier Lab Bioinformatics Group

1.A.80 The NS4a Viroporin (NS4a) Family

The NS4a peptide (54 aas; 1 TMS) has been shown to form pores (Madan et al., 2007). This protein is related to and represents a peptide fragment of the large glycoproteins of the Hepatitis C Virus P7 Viroporin Cation-selective Channel (HCV-P7) Family (TC# 1.A.53).

References associated with 1.A.80 family:

Madan, V., S. Sánchez-Martínez, N. Vedovato, G. Rispoli, L. Carrasco, and J.L. Nieva. (2007). Plasma membrane-porating domain in poliovirus 2B protein. A short peptide mimics viroporin activity. J. Mol. Biol. 374: 951-964. 17963782