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1.A.82.1.1
Mechanotransduction channel complex of cochlear hair cells encoded by the Lhfpl5 gene.  Contains several proteins:  the tetraspan membrane protein of hair cell stereocilia, (TMHS protein) or Lipoma HMGIC fusion partner-like 5 protein (LHFPL5) (Fettiplace 2016), the Protocadherin-15 protein, PCDH15, and the Tmc1 and Tmc2 proteins (TC# 1.A.17) (Xiong et al. 2012).  TMHS and PCDH15 interact directly with Tmc1 and Tmc2, and these interactions are required for mechanotransduction (Maeda et al. 2014; Beurg et al. 2015). A primary function of Tmc1 may be calcium transport (Beurg et al. 2015).  Hair cells express two molecularly and functionally distinct mechanotransduction channels with different subcellular distributions. One is activated by sound and is responsible for sensory transduction. This sensory transduction channel is expressed in hair cell stereocilia, and its activity is affected by mutations in the genes encoding the transmembrane proteins TMHS (this family), TMIE (TC family 9.A.30), TMC1 and TMC2 (family 1.A.17.4) (Wu et al. 2016). Thus, these 4 proteins may all be parts of a single channel complex.  The other channel is the Piezo2 channel (TC# 1.A.75.1.2). TMHS is 68% identical to the human LHFPL3 protein (Q86UP9), and 62% identical to the human LHFPL4 protein (Q7Z7J7). The structure of protocadherin 15 with the tetraspan, LHFP5, has been determined (Ge et al. 2018).

Accession Number:Q8TAF8
Protein Name:Tetraspan membrane protein of hair cell stereocilia
Length:219
Molecular Weight:24201.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

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FASTA formatted sequence
1:	MVKLLPAQEA AKIYHTNYVR NSRAVGVMWG TLTICFSVLV MALFIQPYWI GDSVNTPQAG 
61:	YFGLFSYCVG NVLSSELICK GGPLDFSSIP SRAFKTAMFF VALGMFLIIG SIICFSLFFI 
121:	CNTATVYKIC AWMQLAAATG LMIGCLVYPD GWDSSEVRRM CGEQTGKYTL GHCTIRWAFM 
181:	LAILSIGDAL ILSFLAFVLG YRQDKLLPDD YKADGTEEV