TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.85.1.1









The human poliovirus 2B viroporin (from the polyprotein). The 97 residue 2B viroporin consists of residues 1031-1127 in the polyprotein.  in vitro and in vivo translation-glycosylation compatible with the translocon-mediated insertion of the 2B product into the ER membrane as a double-spanning integral membrane protein with an N-/C-terminal cytoplasmic orientation has been reported (Agirre et al. 2008; Martínez-Gil et al. 2011). The in vitro translation of several truncated versions of the 2B protein suggests that the two hydrophobic regions cooperate to insert into the ER-derived microsomal membranes. The 3A viroporin of poliovirus transports monovalent cations (Hyser and Estes 2015).

Viruses
Picornavirales
2B viroporin of Human poliovirus 1 (Q9Q280)
*1.A.85.1.2









2B protein (99 aas) derived from the polyprotein of human coxsackie virus (Patargias et al., 2009).

Viruses
Picornavirales
B2 capsid protein of the human coxsackie virus. (Q5MP79)
*1.A.85.1.3









Echovirus E30 polyprotein (128 aas; fragment).  An intracellular (endomembrane) pore-forming peptide toxin which induces membrane permeability due to two consecutive hydrophobic segments that may form an α-helix-turn-α-helix hairpin membrane anchor that provides the basis for oligomeric pore formation (Sánchez-Martínez et al. 2012).  This protein is derived from the Coxsackle virus B2 protein of 2187 aas (Q9YLG5) and may interact with a Ryanodine receptor (Schilling et al. 2013).

Viruses
Picornavirales
Polyprotein, including the 100 aa viroporin of human enterovirus (echovirus E30)
*1.A.85.1.4









Polyprotein of 2333 aas (includes the viroporin peptide, NS2B).  Viroporin activity for the NS2B protein has been demonstrated (Ao et al. 2015).

Viruses
Picornavirales
Viroporin-containing polyprotein of foot-and-mouth disease virus
*1.A.85.1.5









Rat picornavirus 2B protein of 116 as and 2 TMSs, a membrane active peptide (Sánchez-Martínez et al. 2012).

Viruses
Picornavirales
2B protein of rat picornavirus
*1.A.85.1.6









The genome polyprotein of 2292 aas encoding the viroporin of Encephalomyocarditis virus (Ito et al. 2012).

Viruses
Picornavirales
Polyprotein of Encephalomyocarditis virus
*1.A.85.1.7









Human rhinovirus 1A 2B protein of 2157 aas

Viruses
Picornavirales
2B of human rhionvirus 1A
*1.A.85.1.8









The Viroporin, protein 2B, of 154 aas and 3 TMSs where TMS 2 provides the channel activity.  Transports cations, Ca2+ and small molecules (Gladue et al. 2018).  Present within the Polyprotein of 2332 aas. 

Viruses
Picornavirales
Poly protein of foot-and-mouth disease virus (FMDV)