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1.A.85.1.4
Polyprotein of 2333 aas (includes the viroporin peptide, NS2B).  Viroporin activity for the NS2B protein has been demonstrated (Ao et al. 2015).

Accession Number:P03308
Protein Name:Genome polyprotein
Length:2333
Molecular Weight:259162.00
Species:Foot-and-mouth disease virus (isolate Bovine/United Kingdom/A12Valle119/1932 serotype A) (FMDV) [12114]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Host cytoplasmic vesicle membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate small molecules

Cross database links:

Structure:
1BCV     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTTNCFIAL VHAIREIRAF FLSRATGKME FTLYNGERKT FYSRPNNHDN CWLNTILQLF 
61:	RYVDEPFFDW VYNSPENLTL AAIKQLEELT GLELHEGGPP ALVIWNIKHL LQTGIGTASR 
121:	PSEVCMVDGT DMCLADFHAG IFLKGQEHAV FACVTSNGWY AIDDEDFYPW TPDPSDVLVF 
181:	VPYDQEPLNG GWKANVQRKL KGAGQSSPAT GSQNQSGNTG SIINNYYMQQ YQNSMDTQLG 
241:	DNAISGGSNE GSTDTTSTHT TNTQNNDWFS KLASSAFTGL FGALLADKKT EETTLLEDRI 
301:	LTTRNGHTTS TTQSSVGVTY GYSTEEDHVA GPNTSGLETR VVQAERFFKK FLFDWTTDKP 
361:	FGHLEKLELP TDHHGVFGHL VDSYAYMRNG WDVEVSAVGN QFNGGCLLVA MVPEWKEFDK 
421:	REKYQLTLFP HQFISPRTNM TAHITVPYLG VNRYDQYKKH KPWTLVIMVV SPLTVSNTAA 
481:	TQIKVYANIA PTYVHVAGEL PSKEGIFPVA CSDGYGGLVT TDPKTADPVY GKVYNPPRTN 
541:	YPGRFTNLLD VAEACPTFLC FDDGKPYVVT RTDDTRLLAK FDVSLAAKHM SNTYLSGIAQ 
601:	YYTQYSGTIN LHFMFTGSTD SKARYMVAYI PPGVETPPET PEGAAHCIHA EWDTGLNSKF 
661:	TFSIPYVSAA DYAYTASDTA ETTNVQGWVC IYQITHGKAE GDTLVVSASA GKDFELRLPI 
721:	DPRSQTTATG ESADPVTTTV ENYGGETQVQ RRHHTDVSFI MDRFVKIKSL NPTHVIDLMQ 
781:	THQHGLVGAL LRAATYYFSD LEIVVRHDGN LTWVPNGAPE AALSNTGNPT AYNKAPFTRL 
841:	ALPYTAPHRV LATVYNGTNK YSASGSGVRG DSGSLAPRVA RQLPASFNYG AIKAETIHEL 
901:	LVRMKRAELY CPRPLLAIEV SSQDRHKQKI IAPGKQLLNF DLLKLAGDVE SNPGPFFFAD 
961:	VRSNFSKLVD TINQMQEDMS TKHGPDFNRL VSAFEELATG VKAIRTGLDE AKPWYKLIKL 
1021:	LSRLSCMAAV AARSKDPVLV AIMLADTGLE ILDSTFVVKK ISDSLSSLFH VPAPVFSFGA 
1081:	PVLLAGLVKV ASSFFRSTPE DLERAEKQLK ARDINDIFAI LKNGEWLVKL ILAIRDWIKA 
1141:	WIASEEKFVT TTDLVPGILE KQRDLNDPSK YKEAKEWLDN ARQACLKSGN VHIANLCKVV 
1201:	APAPSKSRPE PVVVCLRGKS GQGKSFLANV LAQAISTHFT GRTDSVWYCP PDPDHFDGYN 
1261:	QQTVVVMDDL GQNPDGKDFK YFAQMVSTTG FIPPMASLED KGKPFNSKVI IATTNLYSGF 
1321:	TPRTMVCPDA LNRRFHFDID VSAKDGYKIN NKLDIIKALE DTHTNPVAMF QYDCALLNGM 
1381:	AVEMKRMQQD MFKPQPPLQN VYQLVQEVIE RVELHEKVSS HPIFKQISIP SQKSVLYFLI 
1441:	EKGQHEAAIE FFEGMVHDSI KEELRPLIQQ TSFVKRAFKR LKENFEIVAL CLTLLANIVI 
1501:	MIRETRKRQK MVDDAVNEYI EKANITTDDT TLDEAEKNPL ETSGASTVGF RERTLTGQRA 
1561:	CNDVNSEPAR PAEEQPQAEG PYTGPLERQR PLKVRAKLPQ QEGPYAGPLE RQKPLKVKAK 
1621:	APVVKEGPYE GPVKKPVALK VKAKNLIVTE SGAPPTDLQK MVMGNTKPVE LILDGKTVAI 
1681:	CCATGVFGTA YLVPRHLFAE KYDKIMLDGR AMTDSDYRVF EFEIKVKGQD MLSDAALMVL 
1741:	HRGNRVRDIT KHFRDTARMK KGTPVVGVVN NADVGRLIFS GEALTYKDIV VCMDGDTMPG 
1801:	LFAYKAATKA GYCGGAVLAK DGADTFIVGT HSAGGNGVGY CSCVSRSMLL RMKAHVDPEP 
1861:	HHEGLIVDTR DVEERVHVMR KTKLAPTVAH GVFNPEFGPA ALSNKDPRLN EGVVLDEVIF 
1921:	SKHKGDTKMS AEDKALFRRC AADYASRLHS VLGTANAPLS IYEAIKGVDG LDAMESDTAP 
1981:	GLPWAFQGKR RGALIDFENG TVGPEVEAAL KLMEKREYKF ACQTFLKDEI RPMEKVRAGK 
2041:	TRIVDVLPVE HILYTRMMIG RFCAQMHSNN GPQIGSAVGC NPDVDWQRFG THFAQYRNVW 
2101:	DVDYSAFDAN HCSDAMNIMF EEVFRTDFGF HPNAEWILKT LVNTEHAYEN KRITVEGGMP 
2161:	SGCSATSIIN TILNNIYVLY ALRRHYEGVE LDTYTMISYG DDIVVASDYD LDFEALKPHF 
2221:	KSLGQTITPA DKSDKGFVLG HSITDVTFLK RHFHIDYGTG FYKPVMASKT LEAILSFARR 
2281:	GTIQEKLTSV AGLAVHSGPD EYRRLFEPFQ GLFEIPSYRS LYLRWVNAVC GDA