TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.87.1.1









Plant Ca2+ channel protein, Mid1 complementary activity 1, MCA1 (Iida et al. 2013).  MCA1 and MCA2 each forms a homotetramer and exhibit Ca2+-permeable MS channel activity.  Both are single-pass type I transmembrane proteins with their N-termini located extracellularly and their C-termini located intracellularly. An EF hand-like motif, coiled-coil motif, and Plac8 motif may all be in the cytoplasm, suggesting that the activities of both channels can be regulated by intracellular Ca2+ and protein interactions (Kamano et al. 2015). However, hydropathy plots suggest that the Plac8 domain may be transmembrane with 3 TMSs.  mca1 but not mca2 mutants show defects in root entry into hard agar, whereas mca2 but not mca1 mutants are defective in Ca2+ uptake in A. thaliana roots (Hamilton et al. 2015).

Eukaryota
Viridiplantae
MCA1 of Arabidopsis thaliana
*1.A.87.1.2









Plant Ca2+ channel protein, Mid1 complementary activity 2, MCA2 (Iida et al. 2013).  Catalyzes mechanical stress-induced Ca2+ influx.  It is tetrameric with a small transmembrane domain and a large cytoplasmic domain (Shigematsu et al. 2014).  MCA1 and MCA2 both have their N-termini located extracellularly and their C-termini located intracellularly. An EF hand-like motif, coiled-coil motif, and Plac8 motif may all be in the cytoplasm, suggesting that the activities of both channels can be regulated by intracellular Ca2+ and protein interactions (Kamano et al. 2015). However hydropathy plots suggest that the Plac8 domain may be transmembrane with 3 TMSs.  mca1 but not mca2 mutants show defects in root entry into hard agar, whereas mca2 but not mca1 mutants are defective in Ca2+ uptake in A. thaliana roots (Hamilton et al. 2015).

Eukaryota
Viridiplantae
MCA2 of Arabidopsis thaliana
*1.A.87.1.3









MCA1 isoform X2 of 377 aas

Eukaryota
Viridiplantae
MCA1 of Solanum pennellii (Lycopersicon pennellii)
*1.A.87.1.4









PLAC8 family protein of 385 aas.

Eukaryota
Viridiplantae
PLAC8 family protein of Theobroma cacao
*1.A.87.1.5









Mid1 complementing activity 1 of 154 aa

Eukaryota
Viridiplantae
MCA1 of Vigna radiata
*1.A.87.2.1









Receptor protein kinase of 567 aas.  The first 140 aas are homologous to the N-terminal domains of MCA1 and 2; residues 240 - 430 are homologous to ser/thr protein kinases of 9.A.15.1.1, 9.B.45.1.3 and 9.B.106.3.1.

Eukaryota
Viridiplantae
Receptor protein kinase of Zea mays
*1.A.87.2.2









Protein kinase domain protein of 522 aas.

Eukaryota
Viridiplantae
PKD protein of Oryza sativa
*1.A.87.2.3









Receptor for extracellular ATP which functions in plant growth, development and stress responses; lectin receptor kinase 1.9; DORN1.  Binds ATP with high affinity (46nM) and is required ofr ATP-induced calcium response, mitogen-activated protein kinase activation and normal gene expression (Choi et al. 2014).

Eukaryota
Viridiplantae
DORN1 of Arabidopsis thaliana
*1.A.87.2.4









GHR1 (GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1) transmembrane receptor-like protein of 1053 aas and 1 - 3 TMSs.  Regulates the SLAC1 protein (2.A.16.5.1) (Wang et al. 2017). The C-terminus shows extensive sequence similarity with members of this family, but the N-terminus shows similarity with members of family 3.A.20 (Leucine repeat proteins).

Eukaryota
Viridiplantae
GHR1 of Arabidopsis thaliana
*1.A.87.2.5









Uncharacterized protein with an ATP binding domain of 629 aas and 2 TMSs.

Eukaryota
Viridiplantae
UP of Arabidopsis thaliana
*1.A.87.2.6









Protein BRASSINOSTEROID INSENSITIVE 1, BRI1, of 1196 aas and 2 or 3 TMSs. Receptor with kinase activity acting on both serine/threonine- and tyrosine-containing substrates. In response to brassinosteroid binding, it regulates a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. It binds brassinolide, and less effectively, castasterone (Oh et al. 2009).

Eukaryota
Viridiplantae
BRI1 of Arabidopsis thaliana
*1.A.87.3.1









Plant cadmium resistance, PCR, protein of 164 aas.  Shows homology to the C-terminal PLAC8 domain of MCA1 and 2.

Eukaryota
Viridiplantae
Cadmium resistance protein of Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
*1.A.87.3.2









Plant Cadmium Resistance (PCR) protein. This protein corresponds to the C-terminal PLAC8 domain of MCA1 (TC# 1.A.87.1.1) (Song et al., 2011).

Eukaryota
Viridiplantae
PLAC8 family protein of Arabidopsis thaliana
*1.A.87.3.3









Sea squirt membrane protein of 110 aas

Eukaryota
Metazoa
Membrane protein of Ciona intestinalis
*1.A.87.3.4









Uncharacterized protein of 161 aas

Eukaryota
Viridiplantae
UP of Capsella rubella
*1.A.87.3.5









Plant cadmium resistance 6 protein, CadR6, of 224 aas.

Eukaryota
Viridiplantae
CadR6 of Arabidopsis thaliana
*1.A.87.3.6









Uncharacterized protein of 186 aas

Eukaryota
Viridiplantae
UP of Glycine max
*1.A.87.3.7









Plant cadmium resistance 1 protein of 151 aas and 2 TMSs. PCR1.  Involved in glutathione-independent cadmium resistance. Reduces cadmium uptake rather than activating efflux, but is not closely coupled to calcium transport (Song et al. 2011).

Eukaryota
Viridiplantae
PCR1 of Arabidopsis thaliana
*1.A.87.3.8









Plant cadmium resistance 2 (PCR2) protein.  Zinc ion exporter (Song et al. 2010; Song et al. 2011).  Involved in glutathione-independent cadmium resistance. Reduces cadmium uptake rather than activating efflux, but is not closely coupled to calcium transport.

Eukaryota
Viridiplantae
PCR2 of Arabidopsis thaliana
*1.A.87.3.9









FW2.2-like (FWL) protein of 180 aas and 2 TMSs.  Involved in plant and fruit development, and possibly in calcium transport (Libault and Stacey 2010).

Eukaryota
Viridiplantae
FWL of Persea americanan (Avocado)
*1.A.87.3.10









Fruit-weight 2.2 protein of 197 aas and 3 TMSs.  May be involved in Cd2+ resistance as well as  translocation of Cd2+ from roots to shoots (Xiong et al. 2018). May form homooligomeric structures in the membrane.

Eukaryota
Viridiplantae
FWL protein of Medicago truncatula (Barrel medic) (Medicago tribuloides)
*1.A.87.3.11









Fruit-weight 2.2 protein of 161 aas and 4 TMSs.  May be involved in Cd2+ resistance as well as  translocation of Cd2+ from roots to shoots (Xiong et al. 2018).  May form homooligomeric structures in the membrane.

Eukaryota
Viridiplantae
FWL protein of Medicago truncatula (Barrel medic) (Medicago tribuloides)
*1.A.87.4.1









Ubiquitin protein ligase with the first 250 aas homologous to MCA2.

Eukaryota
Viridiplantae
Ubiquitin ligase of Physcomitrella patens
*1.A.87.4.2









U box containing protein 15

Eukaryota
Viridiplantae
U box protein of Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
*1.A.87.5.1









Protein kinase_Tyr of 657 aas with N-terminal domain similar to that of MCA1, with N-terminal TMS containing a conserved aspartyl residue.

Eukaryota
Fungi
PKinase-Tyr of Phanerochaete carnosa