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1.A.9.1.10
The nicotinic acetylcholine receptor alpha 6 isoform 1 of 505 aas and 6 or 7 putative TMSs, with one N-terminal TMS, one C-terminal TMS, and 4 or 5 centrally located TMSs.  66% identical to TC# 1.A.9.1.6.  A 3 aa deletion in the transmembrane domain causes resistance to spinosad, a macrocyclic lactone insecticide (Wang et al. 2016). Mutations in the orthologous α6 subunit of Rhyzopertha dominica (lesser grain borer; 81% identical to the moth protein) also gave rise to spanosad resistance (Wang et al. 2018).

Accession Number:D3JL32
Protein Name:Nicotinic acetylcholine receptor alpha 6 isoform 1
Length:505
Molecular Weight:56992.00
Species:Plutella xylostella (Diamondback moth) [51655]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions and small molecules

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVLLAAALL LALLPVSEQG PHEKRLLNAL LASYNTLERP VANESEPLEV RFGLTLQQII 
61:	DVDEKNQILT TNVWLNLEWN DYNLRWNDSE FGGVKDLRIT PNKLWKPDVL MYNSADEGFD 
121:	GTYQTNVVVR SSGSCLYVPP GIFKSTCKMD ITWFPFDDQH CDMKFGSWTY DGNQLDLVLK 
181:	DENGGDLSDF ITNGEWYLIG MPGKKNTITY ACCPEPYVDV TFTIMIRRRT LYYFFNLIVP 
241:	CVLISSMALL GFTLPPDSGE KLTLGVTILL SLTVFLNLVA ETLPQVSDAI PLLGTYFNCI 
301:	MFMVASSVVL TVVVLNYHHR TADIHEMPQW IKSVFLQWLP WILRMSRPGK KITRKTIMMS 
361:	NRMRELELKE RSSKSLLANV LDIDDDFRHV PPAPNSTAST GNLGPGCSIF RSDFRRSFVR 
421:	PSTMEDVGGG LGGLGGGHHR ELHLILRELQ FITARMKKAD EEAELISDWK FAAMVVDRFC 
481:	LFVFTLFTII ATVAVLLSAP HIIVQ