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1.A.9.1.11
Acetylcholine-activated cation-selective channel, alpha-type, Acr-16 of 504 aas and 6 putative TMSs.  Four negative allosteric modulators of this channel in the parasite have been identified (Zheng et al. 2016).

Accession Number:F1KYJ9
Protein Name:Acetylcholine receptor subunit alpha-type acr-16
Length:504
Molecular Weight:57803.00
Species:Ascaris suum (Pig roundworm) [6253]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate inorgamic cations, inorganic cations

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVQRALHYY LCSQLLLHLY AVEGSYHERR LYEDLMRDYN NLERPVANHS QPVTVYLKVS 
61:	LQQIIDVDEK NQIVYVNAWL DYAWNDYKLR WDKEEYGNIT DVRFPAGKIW KPDVLLYNSV 
121:	DATLDSTYPT NMVVYNTGDI SWIPPGIFKI SCKIDIKWFP FDEQRCFFKF GSWTYDGFKL 
181:	DLQPGKGGFD ISEYMPSGEW ALPMTTVSRT EKFYDCCPEP YPDLTFYLHM RRRTLYYGFN 
241:	LIMPCILTTM MTLLGFTLPP DAGEKITLQI TVLLSICFFL SIVSEISPPT SEAVPLLGIF 
301:	FSCCMIVVTA STVFTVYVLN LHYRTPETHE MGITTRTLLL YWFPYILRME RPGVYLTWQT 
361:	LPPLFPCSKP KKHSESLIRN VKDVETGSSR SNSLDVERRV HQYMSGLTNG TGAPMCTVLN 
421:	GGPATVAGAP MDIGQQATLL VLQRIYQELK TITRRMIEAD REGAQSNNWK FAAMVVDRLC 
481:	LYVFTVFIVA SSCGILLSAP YTIA