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1.A.9.3.2
Photoreceptor in large monopolar cells (LMCs) histamine-gated chloride channel, HclA (Ort) (forms homomers, and heteromers with HclB; homomers resemble native LMC receptors (Pantazis et al., 2008)). hclA mutations lead to defects in the visual system, neurologic disorders and changed responsiveness to neurotoxins (Iovchev et al. 2006).    

Accession Number:A1KYB4
Protein Name:Ort
Length:485
Molecular Weight:55532.00
Species:Drosophila melanogaster GN=ort PE=2 SV=1 [7227]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

Pfam: PF02931    PF02932   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0005230 F:extracellular ligand-gated ion channel acti...
GO:0030534 P:adult behavior
GO:0006811 P:ion transport
GO:0045472 P:response to ether
GO:0009636 P:response to toxin
GO:0007268 P:synaptic transmission

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVFQIIILVI CTICMKHYAK GEFQQSLAIT DILPEDIKRY DKMRPPKKEG QPTIVYFHVT 
61:	VMGLDSIDEN SMTYVADVFF AQTWKDHRLR LPENMTQEYR LLEVDWLKNM WRPDSFFKNA 
121:	KSVTFQTMTI PNHYMWLYKD KTILYMVKLT LKLSCIMNFA IYPHVTQECK LQMESLSHTT 
181:	DDLIFQWDPT TPLVVDENIE LPQVALIRNE TADCTQVYST GNFTCLEVVF TLKRRLVYYV 
241:	FNTYIPTCMI VIMSWVSFWI KPEAAPARVT LGVTSLLTLS TQHAKSQSSL PPVSYLKAVD 
301:	AFMSVCTVFV FMALMEYCLI NIVLSDTPIP KPMAYPPKPV AGDGPKKEGE GAPPGGSNST 
361:	ASKQQATMLP LADEKIEKIE KIFDEMTKNR RIVTTTRRVV RPPLDADGPW IPRQESRIIL 
421:	TPTIAPPPPP PQPAAPEPEL PKPKLTPAQE RLKRAIYIDR SSRVLFPALF ASLNGIYWCV 
481:	FYEYL