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1.A.9.3.3
Photoreceptor LMC histamine-gated chloride channel HclB (HisCl1) (forms homomers as well as heteromers with HclA; homomers and heteromers are more sensitive to histamine but with smaller conductance that of HclA (Pantazis et al., 2008)).

Accession Number:Q8WS32
Protein Name:HisCl1 aka HclB
Length:422
Molecular Weight:48896.00
Species:Drosophila melanogaster GN=HisCl1 PE=2 SV=1 [7227]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

RefSeq: NP_650116.2   
Entrez Gene ID: 41426   
Pfam: PF02931    PF02932   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0005230 F:extracellular ligand-gated ion channel acti...
GO:0006811 P:ion transport

References (4)

[1] “Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye.”  Zheng Y.et.al.   11714703
[2] “Two cDNAs coding for histamine-gated ion channels in D. melanogaster.”  Gisselmann G.et.al.   11753412
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQSPTSKLVE FRCLIALAIY LHALEQSIQH CHCVHGYRNN TESAELVSHY ESSLSLPDIL 
61:	PIPSKTYDKN RAPKLLGQPT VVYFHVTVLS LDSINEESMT YVTDIFLAQS WRDPRLRLPE 
121:	NMSEQYRILD VDWLHSIWRP DCFFKNAKKV TFHEMSIPNH YLWLYHDKTL LYMSKLTLVL 
181:	SCAMKFESYP HDTQICSMMI ESLSHTVEDL VFIWNMTDPL VVNTEIELPQ LDISNNYTTD 
241:	CTIEYSTGNF TCLAIVFNLR RRLGYHLFHT YIPSALIVVM SWISFWIKPE AIPARVTLGV 
301:	TSLLTLATQN TQSQQSLPPV SYVKAIDVWM SSCSVFVFLS LMEFAVVNNF MGPVATKAMK 
361:	GYSDENISDL DDLKHHRESI IEPQYDTFCH GHATAIYIDK FSRFFFPFSF FILNIVYWTT 
421:	FL