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1.A.9.4.1
Glutamate-inhibited chloride (anion-selective) channel, CIα chain.  This protein is 98% identical to the ortholog in Musca domestica (the house fly).  Fluralaner (Bravecto) is an isoxazoline ectoparasiticide which potently inhibits GABA-gated chloride channels (GABACls) and less potently glutamate-gated chloride channels (GluCls) in insects. The amino acid, Leu315, in Musca GluCls is important in determining the selectivity of fluralaner and ivermectin which react in opposite ways (Nakata et al. 2017).

Accession Number:Q94900
Protein Name:GLUCL-ALPHA aka DROSGLUCL aka CG7535
Length:456
Molecular Weight:52307.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

eggNOG: inNOG07594
RefSeq: NP_001014641.1    NP_001034061.1    NP_650827.2    NP_732447.1   
Entrez Gene ID: 42350   
Pfam: PF02931    PF02932   
KEGG: dme:Dmel_CG7535   

Gene Ontology

GO:0030054 C:cell junction
GO:0034707 C:chloride channel complex
GO:0045211 C:postsynaptic membrane
GO:0008068 F:extracellular-glutamate-gated chloride chan...
GO:0004872 F:receptor activity
GO:0006821 P:chloride transport

References (6)

[1] “Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin.”  Cully D.F.et.al.   8702744
[2] “Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications.”  Semenov E.P.et.al.   9886055
[3] “Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.”  Kane N.S.et.al.   11095718
[4] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[5] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[6] “A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.”  Palladino M.J.et.al.   10966106

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGSGHYFWAI LYFASLCSAS LANNAKINFR EKEKKVLDQI LGAGKYDARI RPSGINGTDG 
61:	PAIVRINLFV RSIMTISDIK MEYSVQLTFR EQWTDERLKF DDIQGRLKYL TLTEANRVWM 
121:	PDLFFSNEKE GHFHNIIMPN VYIRIFPNGS VLYSIRISLT LACPMNLKLY PLDRQICSLR 
181:	MASYGWTTND LVFLWKEGDP VQVVKNLHLP RFTLEKFLTD YCNSKTNTGE YSCLKVDLLF 
241:	KREFSYYLIQ IYIPCCMLVI VSWVSFWLDQ GAVPARVSLG VTTLLTMATQ TSGINASLPP 
301:	VSYTKAIDVW TGVCLTFVFG ALLEFALVNY ASRSGSNKAN MHKESMKKKR RDLEQASLDA 
361:	ASDLLDTDSN ATFAMKPLVR HPGDPLALEK RLQCEVHMQA PKRPNCCKTW LSKFPTRQCS 
421:	RSKRIDVISR ITFPLVFALF NLVYWSTYLF REEEDE