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1.A.9.4.3
Glutamate-gated chloride channel, GluC1 or Glc-4 (Yamaguchi et al., 2012). Ivermectin, an anthelminthic drug, inhibits neuronal activity and muscular contractility in arthropods and nematodes, activating glutamate-gated chloride channels at nanomolar concentrations (Lynagh and Lynch, 2012; Zemkova et al. 2014). 

Accession Number:P91730
Protein Name:Glutamate-gated chloride channel subunit beta
Length:432
Molecular Weight:49626.00
Species:Haemonchus contortus (Barber pole worm) [6289]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

Pfam: PF02931    PF02932   

Gene Ontology

GO:0030054 C:cell junction
GO:0034707 C:chloride channel complex
GO:0005886 C:plasma membrane
GO:0045211 C:postsynaptic membrane
GO:0005254 F:chloride channel activity
GO:0005230 F:extracellular ligand-gated ion channel activity
GO:0004872 F:receptor activity

References (1)

[1] “Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus.”  Delany N.S.et.al.   9879896

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQYMMVAVA AVVAVAGSSQ ISRRSTGGTQ EQEILNELLS NYDMRVRPPP SNYSDPMGPV 
61:	TVRVNIMIRM LSKIDVVNME YSMQLTFREQ WLDSRLAYAH LGYHNPPKFL TVPHIKSNLW 
121:	IPDTFFPTEK AAHRHLIDTD NMFLRIHPDG KVLYSSRISI TSSCHMQLQL YPLDLQFCDF 
181:	DLVSYAHTMK DIVYEWDPLA PVQLKPGVGS DLPNFQLTNI TTNDDCTSHT NTGSYACLRM 
241:	QLTLKRQFSY YLVQLYGPTT MIVIVSWVSF WIDMHSTAGR VALGVTTLLT MTTMQAAINA 
301:	KLPPVSYVKV VDVWLGACQT FVFGALLEYA FVSYQDSQRQ TEQAKSRAAR KAQKRRAKME 
361:	LVEREQYQPP CTCHLYQDYE PSFRDRLRRY FTKPDYLPAK IDYYARFCVP LGFLAFNAIY 
421:	WTSCLVMVSR LV