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1.A.9.4.5
Glutamate-gated chloride channel of 448 aas, GluCl.  A point mutation, A309V in TMS 3, renders the protein and the organism > 11,000-fold resistant to abamectin, an insecticide of this moth, which is a global pest of cruciferous vegetables (Wang et al. 2015). Both A309V and G315E mutations contribute to target-site resistance to abamectin (Wang et al. 2017). Fluralaner (Bravecto) is an isoxazoline ectoparasiticide which potently inhibits GABA-gated chloride channels (GABACls) and less potently glutamate-gated chloride channels (GluCls) in insects. The amino acid, Leu315, in Musca (fly) GluCls is important in determining the selectivity of fluralaner and ivermectin which react in opposite ways (Nakata et al. 2017).  

Accession Number:I7B325
Protein Name:Glutamate-gated chloride channel
Length:448
Molecular Weight:51656.00
Species:Plutella xylostella (Diamondback moth) [51655]
Number of TMSs:4
Substrate Cl-

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FASTA formatted sequence
1:	MDVLRPSCAL FVLFLLYCAH LTECVNAKIN FREKEKQILD QILGPGRYDA RIRPSGINGT 
61:	GDAPTLVRVN LYLRSISKID DYKMEYSVQL TFREQWLDER LKFNNLGGRL KYLTLTEANR 
121:	VWMPDLFFSN EKEGHFHNII MPNVYIRIFP NGNVLYSIRI SLTLSCPMNL KLYPLDKQTC 
181:	SLRMASYGWT TDDLVFLWKE GDPVQVVKNL HLPRFTLEKF LTDYCNSKTN TGEYSCLKVD 
241:	LLFKREFSYY LIQIYIPCCM LVIVSWVSFW LDQGAVPARV SLGVTTLLTM ATQSSGINAS 
301:	LPPVSYTKAI DVWTGVCLTF VFGALLEFAL VNYASRSDMH RENMKKTRRE MEAAASMDAA 
361:	SDLLDTDSNA TFAMKPLMRG AVLDSKMRQC EVHMAPPRKN CCRLWMSKFP TRSKRIDVIS 
421:	RITFPLVFAL FNLAYWSTYL FRDEDEED