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1.A.9.4.6
Glutamate-gated chloride channel exon 3c variant of 447 aas and 5 TMSs. Okaramines produced by Penicillium simplicissimum AK-40 activate l-glutamate-gated chloride channels (GluCls) and thus paralyze insects. The B. mori GluCl containing the L319F mutation retained its sensitivity to l-glutamate, but responses to ivermectin were reduced and those to okaramine B were completely eliminated (Furutani et al. 2017).

Accession Number:V9P9Q8
Protein Name:Glutamate gated chloride channel exon 3c variant
Length:447
Molecular Weight:51703.00
Species:Bombyx mori (Silk moth) [7091]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell junction1
Substrate

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FASTA formatted sequence
1:	MEFPRRPCAL LVLILSYFTQ LAICMNSGKI NFREKEKQIL DQILGPGRYD ARIRPSGING 
61:	TGDAPTLVRV NMYLRSISKI DDYKMEYSVQ LTFREQWLDE RLKFNNLGGR LKYLTLTEAN 
121:	RVWMPDLFFS NEKEGHFHNI IMPNVYIRIF PNGTVLYSIR ISLTLSCPMN LKLYPLDKQT 
181:	CSLRMASYGW TTDDLVFLWK EGDPVQVVKN LHLPRFTLEK FRTDYCNSKT NTGEYSCLKV 
241:	DLLFKREFSY YLIQIYIPCC MLVIVSWVSF WLDQGAVPAR VSLGVTTLLT MATQSSGINA 
301:	SLPPVSYTKA IDVWTGVCLT FVFGALLEFA LVNYASRSDM HRENMKKTRR EMEAASMDAA 
361:	SDLLDTDSNA TFAMKPLVRG GVDTKMRQCE IHISQPRKNC CRLWMSKFPT RSKRIDVISR 
421:	ITFPLVFAIF NLAYWSTYLF RDEEEEK