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1.A.9.7.1
γ-aminobutyric acid (GABA)-gated cation channel, EXP-1

Accession Number:Q9TZI5
Protein Name:Expulsion defective (Defecation) protein 1 aka Exp-1
Length:539
Molecular Weight:62554.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

HEGENOM: HBG379853
RefSeq: NP_495229.3   
Entrez Gene ID: 186801   
Pfam: PF02931    PF02932   
KEGG: cel:H35N03.1   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0005230 F:extracellular ligand-gated ion channel acti...
GO:0004872 F:receptor activity
GO:0009792 P:embryonic development ending in birth or eg...
GO:0006811 P:ion transport

References (2)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “EXP-1 is an excitatory GABA-gated cation channel.”  Beg A.A.et.al.   14555952

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSASILILAT CHQVLADFNS YVVPQPHAQR DHRQDISQHY DYLMEENDEP LGRGAAPSKY 
61:	RSSHGQAQHR PEMTESENFA QPNTESVFSS GGVDSYGETR DFLQFLRRIQ YDHRQVPENE 
121:	KGEATYVEVS VVVSNIRAVS EVTMDYALEL FYRESWRDPR LQYDRKLFKN KTELALHESY 
181:	TNFLWFPDTF VPNAIASKNP QRNSISHRSL LRLDETGKLL YSRRISLVCE CTMDLTLFPF 
241:	DKQLCKLGIE SYGYTADHVV YKWSKGARTA LELKKIRLPD FTIQEAYVTS QMESYATGNY 
301:	SRLYVCFVFS RSSGFCFLQL IIPSTAVVIT SWVSLWMETE TEFQDMISII LAITFLIFSY 
361:	NEMMPRVSYI KAMDIYLGVC FMIVFLSLIK LALVKYMRQK IMLTSDSGNS LREMSQMSTR 
421:	QRLRARKTSN MNFRNNGGGS IPINEEHQQM LTVPNGEDKM ANGDDKEANN NGKSHLSDML 
481:	EIRITQRTMH RFHWISQMLF FFGFVIFCLF YFLIYPNLHI VSVDPACDKN LAEWFADIY