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1.A.9.9.1
The bacterial pentameric Cys-loop ligand-gated ion channel, ELIC. A 3.3 Å resolution structure is available (Hilf and Dutzler, 2008; Corringer et al., 2010).  X-ray analyses have identified three distinct binding sites for anaesthetics, one in the channel, one at the end of a TMS, and one in a hydrophobic pocket of the extracellular domain (Spurny et al. 2013).  Motions involving desensitization have been defined (Dellisanti et al. 2013).  Simulations indicate the similarities with and differences between the Acetylcholine receptor (Cheng et al. 2009).  This family includes members with very divergent properties (Gonzalez-Gutierrez and Grosman 2015).  Cysteamine is an agonist for ELIC (Hénault and Baenziger 2016). X-ray structures and functional measurements support a pore-blocking mechanism for the inhibitory action of short-chain alcohols which bind to the TMSs (Chen et al. 2016). GLIC (TC# 1.A.9.8.1) and ELIC may represent distinct transmembrane domain archetypes (Therien and Baenziger 2017).

Accession Number:P0C7B7
Protein Name:Cys-loop ligand-gated ionic channel
Length:321
Molecular Weight:36808.00
Species:Erwinia chrysanthemi [556]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Pfam: PF02931   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005230 F:extracellular ligand-gated ion channel acti...
GO:0006811 P:ion transport

References (1)

[1] “X-ray structure of a prokaryotic pentameric ligand-gated ion channel.”  Hilf R.J.et.al.   18322461
Structure:
2VL0   2YKS   2YOE   3ZKR   4A97   4A98   4TWD   4TWF   4TWH   4YEU   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT PGDKPLIVEN 
61:	TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV IYNARFLGSF SNDMDFRLFP 
121:	FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE NIDNEEIDEW WIRKASTHIS DIRYDHLSSV 
181:	QPNQNEFSRI TVRIDAVRNP SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT 
241:	VVAYAFYTSN ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR 
301:	LAFPLGFLAI GCVLVIRGIT L